Results 31 to 40 of about 77,909 (196)
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
On Maximum Contention-Free Interleavers and Permutation Polynomials over Integer Rings [PDF]
, 2005 An interleaver is a critical component for the channel coding performance of turbo codes. Algebraic constructions are of particular interest because they admit analytical designs and simple, practical hardware implementation. Contention-free interleavers
Takeshita, Oscar Y.
core +2 more sources
Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
Minimal generation of transitive permutation groups [PDF]
, 2018 It is proved in [21] that there is a constant $c$ such that each transitive permutation group of degree $d\ge 2$ can be generated by $\lfloor cd/\sqrt{\log{d}}\rfloor$ elements. In this paper, we explicitly estimate $c$
Tracey, Gareth M.
core +2 more sources
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
On the Cartan matrix of Mackey algebras [PDF]
, 2009 Let k be a field of characteristic p>0, and G be a finite group. The first result of this paper is an explicit formula for the determinant of the Cartan matrix of the Mackey algebra mu_k(G) of G over k.
Bouc, Serge
core +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Enabling computation of correlation bounds for finite-dimensional quantum systems via symmetrisation
, 2018 We present a technique for reducing the computational requirements by several orders of magnitude in the evaluation of semidefinite relaxations for bounding the set of quantum correlations arising from finite-dimensional Hilbert spaces.
Renou, Marc-Olivier +2 more
core +2 more sources