Results 211 to 220 of about 1,026,952 (386)

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

Comparative efficacy of hyperbaric bupivacaine <i>vs</i> hyperbaric ropivacaine in spinal anesthesia for cesarean section: A meta-analysis. [PDF]

World J Methodol
Anand R, Nag DS, Patel R, Sharma P, Uppalapati VK, Singh UK.   +5 more
europepmc   +1 more source

A TRANSATLANTIC STUDY OF NEUROMUSCULAR BLOCKADE

, 1969
Ronald L. Katz, J. N. Norman, R. F. Seed
openalex   +1 more source

Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade

Science, 2016
N. Mcgranahan, A. Furness, R. Rosenthal, S. Ramskov, R. Lyngaa, S. Saini, M. Jamal-Hanjani, G. Wilson, Nicolai J. Birkbak, C. Hiley, T. Watkins, S. Shafi, N. Murugaesu, R. Mitter, A. Akarca, J. Linares, T. Marafioti, J. Henry, E. V. Van Allen, Diana Miao, B. Schilling, D. Schadendorf, L. Garraway, V. Makarov, N. Rizvi, A. Snyder, M. Hellmann, T. Merghoub, J. Wolchok, S. Shukla, Catherine J. Wu, K. Peggs, T. Chan, S. Hadrup, S. Quezada, C. Swanton   +35 more
semanticscholar   +1 more source

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

Improvement of the Anticancer Efficacy of PD-1/PD-L1 Blockade: Advances in Molecular Mechanisms and Therapeutic Strategies. [PDF]

MedComm (2020)
Gao P, Li X, Duan Z, Wang Y, Li Y, Wang J, Luo K, Chen J.   +7 more
europepmc   +1 more source

INFLUENCE OF ADRENERGIC BETA‐RECEPTOR BLOCKADE ON THE ACUTE CARDIOVASCULAR EFFECTS OF HYDRALAZINE* [PDF]

, 1967
H. Brünner, P. R. Hedwall, Max Meier
openalex   +1 more source

INTERCOSTAL BLOCKADE

British Journal of Anaesthesia, 1985
openaire   +2 more sources

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

Molecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte, Osheen Sharma, Laura Leuenberger, Emelie Wallin, Josefin Fernebro, Päivi Östling, Rebecka Bergström, Johan Lindberg, Ulrika Joneborg, Olli Kallioniemi, Brinton Seashore‐Ludlow   +10 more
wiley   +1 more source

TRPV1 inhibition sensitizes tumors to PD-1 blockade by reversing resistance to CTL-mediated killing. [PDF]

Sci Rep
Son MK, Lee HJ, Cho E, Oh SJ, Kim TW.
europepmc   +1 more source