Results 51 to 60 of about 113,652 (316)
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
, 2013 This presentation describes the Bayesian Block algorithm in the context of its application to analysis of time series data from the Fermi Gamma Ray Space Telescope. More generally this algorithm performs optimal segmentation analysis on sequential data in any mode, with arbitrary sampling and in the presence of gaps and exposure variations.
Scargle, Jeffrey D. +3 more
openaire +2 more sources
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Системный анализ и прикладная информатика, 2019 Caches are intermediate level between fast CPU and slow main memory. It aims to store copies of frequently used data and to reduce the access time to the main memory.
A. A. Prihozhy
doaj +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Системный анализ и прикладная информатикаIn this paper we consider two families of competing algorithms for finding the shortest paths between all pairs of vertices (APSP) in directed weighted large graphs with different edge densities: Dijkstra and Floyd-Warshall. For comparison, we have taken
A. A. Prihozhy, O. N. Karasik
doaj +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Threaded block-parallel algorithm for finding the shortest paths on graph
Доклады Белорусского государственного университета информатики и радиоэлектроники, 2019 The problem of finding the shortest paths on weighted graphs is considered. The variants of statement of the problem, known algorithms for it solving, areas of practical application and existing challenges, in particular, the challenge of scalability ...
O. N. Karasik, A. A. Prihozhy
doaj
FEBS Open Bio, EarlyView.Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li +6 more
wiley +1 more source