Results 211 to 220 of about 2,099,864 (251)

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

DNAM-1 mediates NK-cell activation and host-pathogen interaction via direct binding to fungal cell wall proteases. [PDF]

Commun Biol
Natasha F, Heilig L, Helmerich DA, Luther C, Springer J, Kar B, Drobny M, Kasper L, Schuh C, Dittrich M, Hube B, Dandekar T, Sauer M, Löffler J, Terpitz U.   +14 more
europepmc   +1 more source

Sudden anaerobization in Amphibacillus xylanus increases intracellular labile ferrous iron and inhibits cell growth

FEBS Open Bio, EarlyView.
Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata, Yoichi Sakai, Keisuke Tanaka, Etsuro Yoshimura, Ken Kitano, Morio Ishikawa, Tadahiro Nakamoto, Tsutomu Takayama, Hirofumi Inoue, Kaho Nomura, Tomonori Suzuki, Masataka Uchino, Akira Abe, Youichi Niimura   +13 more
wiley   +1 more source

IgG4 anti-CD47: Erythrophagocytosis and potential transfusion complications. [PDF]

Transfusion
Boligan KF, Loriamini M, Holton MB, Sandhu G, Binnington B, Velliquette R, Westhoff CM, Branch DR.   +7 more
europepmc   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Establishment of human-relevant <i>in vitro</i> models using animal-free serum replacement and recombinant antibodies. [PDF]

Front Toxicol
Miri Z, Laakkonen J, Toivonen E, Väljä N, Miettinen S, Vuorenpää H.   +5 more
europepmc   +1 more source

Development of an Indirect ELISA for the Detection of ARV Epidemic Strain xj-1.1. [PDF]

Methods Protoc
Li W, Wang Y, Qi B, Yang L, Ma X, Dang X, Qi Y, Zhang S.   +7 more
europepmc   +1 more source