Results 31 to 40 of about 119,891 (311)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Invalid-Resource-Aware Spectrum Assignment for Advanced-Reservation Traffic in Elastic Optical Network

Sensors, 2020
Elastic optical networks (EONs) can make service accommodation more flexible and precise by employing efficient routing and spectrum allocation (RSA) algorithms. In order to improve the efficiency of RSA algorithms, the advanced-reservation technique was
Shufang He, Yang Qiu, Jing Xu
doaj   +1 more source

A Century-Long Challenge in Teletraffic Theory: Blocking Probability Evaluation for Overflow Loss Systems With Mutual Overflow

IEEE Access, 2023
In this review, we describe historical and recent developments towards tackling a century-long challenge in teletraffic theory, namely the evaluation of blocking probability in overflow systems with mutual overflow. Such systems have many applications in
Eric W. M. Wong, Yin-Chi Chan
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Evaluating QoS in Dynamic Virtual Machine Migration: A Multi-Class Queuing Model for Edge-Cloud Systems

Journal of Sensor and Actuator Networks
The efficient migration of virtual machines (VMs) is critical for optimizing resource management, ensuring service continuity, and enhancing resiliency in cloud and edge computing environments, particularly as 6G networks demand higher reliability and ...
Anna Kushchazli, Kseniia Leonteva, Irina Kochetkova, Abdukodir Khakimov   +3 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Teletraffic and Blocking Probability Estimation of OFDMA System

, 2016
In Wireless communication, to provide good Quality of service (QoS), network operators have to make the effective use of their available resources, which leads to effective network design and network planning.
Rao, Ch. Venkata, Rao, G. Sasibhushana, Prasad, K. Satya   +2 more
core   +1 more source

On the Evaluation of Handover Exchange Schemes Between Two Cognitive Radio Base Stations with and without Buffers [PDF]

International Journal of Electronics and Telecommunications, 2018
This article investigates and evaluates a handover exchange scheme between two secondary users (SUs) moving in different directions across the handover region of neighboring cell in a cognitive radio network.
Ebenezer Esenogho, Elie N. Mambou, Hendrik C. Ferreira   +2 more
doaj   +1 more source