Results 141 to 150 of about 465,440 (342)
The role of randomness in avalanche statistics and synchronization of spring-block models
, 2017 Valentina Esposito
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Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Experimentally Derived and Computationally Optimized Backbone Conformational Statistics for Blocked Amino Acids [PDF]
, 2018 Jeong‐Mo Choi, Rohit V. Pappu
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
SensorsInfrared line-scanning images have high redundancy and large file sizes. In JPEG2000 compression, the MQ arithmetic encoder’s complexity slows down processing. Huffman coding can achieve O(1) complexity based on a code table, but its integer-bit encoding
Yaohua Zhu +5 more
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There Once Was a 9-Block …- A Middle-School Design for Probability and Statistics [PDF]
, 2006 Dor Abrahamson +2 more
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NOMA Joint Decoding based on Soft-Output Ordered-Statistics Decoder for Short Block Codes [PDF]
, 2021 Chentao Yue +7 more
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Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Player versus Player: A systematic review of cyberbullying in multiplayer online games
Computers in Human Behavior ReportsIntroduction: This systematic review evaluates the prevalence, characteristics, and predictors of cyberbullying behaviour in multiplayer online games. Methods: Following the PRISMA framework, seven databases were searched from inception until August 24th,
Hu Yunhao +3 more
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E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source