Results 151 to 160 of about 465,440 (342)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

An algorithm for space–time block code classification using higher-order statistics (HOS) [PDF]

, 2016
Wenjun Yan, Limin Zhang, Qing Ling
openalex   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

When access ≠ acceptance: How clinical specialty demands shape mutual recognition on medical examination/test result reuse in Chinese hospitals: A study on a pilot province of China's medical digital reform.

PLoS ONE
BackgroundDespite widespread electronic health records adoption, interoperability for sharing examination/test results across healthcare institutions remains limited, leading to redundant testing, increased costs, and compromised care.
Chao Song, Xinmian Huang, Shasha Qian, Chaoyun Yuan, Shuning Liu, Jun Zhou   +5 more
doaj   +1 more source

Blending the New Statistics with Mixture Modeling -- A ROPE-based single-block Gibbs sampler for Bayesian t-tests [PDF]

, 2019
Riko Kelter
openalex  

Pseudolikelihood inference for Gibbsian T-tessellations ... and point processes

, 2015
Recently a new class of planar tessellations, named T-tessellations, was introduced. Splits, merges and a third local modification named flip where shown to be sufficient for exploring the space of T-tessellations.
Adamczyk-Chauvat, Katarzyna, Kiêu, Kiên   +1 more
core   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Limit theorems for non-degenerate U-statistics of block maxima for time series [PDF]

, 2023
Axel Bücher, Torben Staud
openalex   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Fast Computation by Block Permanents of Cumulative Distribution Functions of Order Statistics from Several Populations [PDF]

, 2008
D. H. Glueck, A. Karimpour-Fard, J. Mandel, L. Hunter, K. E. Muller   +4 more
openalex   +1 more source