Results 171 to 180 of about 440,099 (344)

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Enhancement of nerve structure segmentation by a correntropy-based pre-image approach

TecnoLógicas, 2017
Peripheral Nerve Blocking (PNB) is a commonly used technique for performing regional anesthesia and managing pain. PNB comprises the administration of anesthetics in the proximity of a nerve.
J. Gil-González, A. Álvarez-Meza, J. Echeverry-Correa, A. Orozco-Gutiérrez, M. Álvarez-López   +4 more
doaj  

Statistics of Random Permutations and the Cryptanalysis Of Periodic Block Ciphers

, 2009
Nicolas T. Courtois, Gregory V. Bard, Shaun V. Ault   +2 more
openalex   +2 more sources

Timber resource statistics for the upper Tanana block, Tanana inventory unit, Alaska, 1974. [PDF]

, 1983
Karl M. Hegg
openalex   +1 more source

Decrypting cancer's spatial code: from single cells to tissue niches

Molecular Oncology, EarlyView.
Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik, Shi Pan, Eloise Withnell, Hou Wang Lam, Maria Secrier   +4 more
wiley   +1 more source

A powerful framework for an integrative study with heterogeneous omics data: from univariate statistics to multi-block analysis

, 2020
Harold Duruflé, Merwann Selmani, Philippe Ranocha, Élisabeth Jamet, Christophe Dunand, Sébastien Déjean   +5 more
openalex   +2 more sources

There Once Was a 9-Block …- A Middle-School Design for Probability and Statistics [PDF]

, 2006
Dor Abrahamson, Ruth M. Janusz, Uri Wilensky   +2 more
openalex   +1 more source

Microglia limit brain tumor development by restricting tumor cell proliferation and inducing T‐cell immunity

Molecular Oncology, EarlyView.
Microglia (BV2) and IL‐4‐treated BMDMs promote astrocytoma clustering and inhibit tumor growth, not shown in other macrophage cells. In vivo, microglial co‐implantation enhances CD8+ T cell infiltration, elevates Granzyme B, lowers circulating MDSCs, and extends survival only in immune‐competent mice, but not in immune‐deficient mice.
Tzu‐Chieh Sun, Ching‐Fang Yu, Sheng‐Yan Wu, Wei‐Chung Cheng, Chi‐Shiun Chiang, Fang‐Hsin Chen   +5 more
wiley   +1 more source

A large-scale dataset for training deep learning segmentation and tracking of extreme weather. [PDF]

Sci Data
Kim S, Graubner A, Kapp-Schwoerer L, Kashinath K, Schindler K.   +4 more
europepmc   +1 more source