FEBS Open Bio, EarlyView.The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida +6 more
wiley +1 more source
A large-scale dataset for training deep learning segmentation and tracking of extreme weather. [PDF]
Sci DataKim S +4 more
europepmc +1 more source
A powerful framework for an integrative study with heterogeneous omics data: from univariate statistics to multi-block analysis [PDF]
, 2018 Harold Duruflé +5 more
openalex +1 more source
Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes
FEBS Open Bio, EarlyView.We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde +3 more
wiley +1 more source
CD154 Restricts Helminth-Induced Macrophage Polarisation and Proliferation While Promoting Tissue Residence. [PDF]
Parasite ImmunolSuárez-Martins M +9 more
europepmc +1 more source
FEBS Open Bio, EarlyView.Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn +4 more
wiley +1 more source
The effect of dexmedetomidine on rocuronium-induced neuromuscular blockade and its reversal by sugammadex. [PDF]
Intensive Care Med ExpFedor M +3 more
europepmc +1 more source
Generating Series for Error Statistics of Block Codes on Channels with Memory
, 1998 Cecílio Pimentel
openalex +2 more sources
Timber resource statistics for the Willow block, Susitna River Basin multiresource inventory unit, Alaska, 1978. [PDF]
, 1984 Theodore S. Setzer +2 more
openalex +1 more source
Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Aging and Cancer, EarlyView.Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source