Results 211 to 220 of about 440,099 (344)

Co‐overexpression of the caloric restriction‐induced mitochondrial factors PGC‐1α and MIPEP upregulates Phospho1 expression in adipocytes

FEBS Open Bio, EarlyView.
Caloric restriction that extends lifespan induces the expression of PGC‐1α and MIPEP in white adipose tissue. In this study, co‐overexpression of Pgc‐1α and Mipep upregulated the gene expression of PHOSPHO1. These findings provide new insights into mitochondria‐related mechanisms underlying the effects of caloric restriction in adipocytes.
Mamiko Ishimatsu, Kanari Taki, Asuka Hayami, Komachi Kato, Yuka Nozaki, Yuhei Mizunoe, Takumi Narita, Ryoichi Mori, Yoshikazu Higami, Masaki Kobayashi   +9 more
wiley   +1 more source

Hepatocellular carcinoma escapes immune surveillance through deceiving thymus into recalling peripheral activated CD8⁺ T cells. [PDF]

Neoplasia
Hu Q, Wang X, You Y, Liu J, Lan B, Chen F, Wen H, Cheng H, Zhuo W, Xu T, Zheng J, Jiang Y, Wang X, Lin J, Guo Z, Huang S, Chen G, Chen Y, Liu J.   +18 more
europepmc   +1 more source

On the statistical testing of block ciphers

, 1999
openaire   +3 more sources

CD9‐association with PIP2 areas is regulated by a CD9 salt bridge

FEBS Open Bio, EarlyView.
The tetraspanin CD9 has an intracellular salt bridge. If CD9 opens, open‐CD9 moves from PIP2‐rich areas to regions populated by its interaction partner EWI‐2. Hence, the state of the salt bridge regulates the distribution of CD9 and by this CD9‐EWI‐2 complex formation.
Yahya Homsi, Sara C. Konopka, Thorsten Lang   +2 more
wiley   +1 more source

Phosphatidylcholine-specific B cells are enriched among atypical CD11c^high and CD21^low memory B cells in antiphospholipid syndrome. [PDF]

Front Immunol
Nitschke E, Dang VD, Rincon-Arevalo H, Szelinski F, Ritter J, Schrezenmeier E, Alexander T, Le TA, Chen Y, Wiedemann A, Gonzalez JB, Lino AC, Stefanski AL, Dörner T.   +13 more
europepmc   +1 more source

Characterization of WAC interactions with R2TP and TTT chaperone complexes linking glucose and glutamine availability to mTORC1 activity

FEBS Open Bio, EarlyView.
TTT and R2TP chaperone complexes are required for the assembly and activation of mTORC1. WAC directly interacts with components of TTT, R2TP, and mTORC1, and these interactions are affected by the availability of glucose and glutamine, correlating with changes in mTORC1 activity.
Sofía Cabezudo, Natalia Cuervo, Carmen García‐Martín, Andrés López‐Perrote, Clara Reglero, Adrián Maqueda‐Real, Ana González‐Corpas, Marina Serna, Diego Megías, Alejo Efeyan, Solip Park, Oscar Llorca   +11 more
wiley   +1 more source

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

FEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, Hubert Schrezenmeier, David Alexander Christian Messerer   +5 more
wiley   +1 more source

Single cell suppression profiling of human regulatory T cells. [PDF]

Nat Commun
Søndergaard JN, Tulyeu J, Priest D, Sakaguchi S, Wing JB.   +4 more
europepmc   +1 more source

Multiband acceleration can provide moderate improvements in single-subject voxel-wise statistics in block-design task-based fMRI [PDF]

, 2019
Ritu Bhandari, Valeria Gazzola, Christian Keysers   +2 more
openalex  

High LRIG1 expression predicts lymph node metastasis in patients with uterine cervical cancer

FEBS Open Bio, EarlyView.
Lymph node status is crucial in determining treatment for women with early‐stage cervical cancer. We demonstrate that high LRIG1 protein expression in primary tumors can predict lymph node metastases. Our findings support further investigation of LRIG1 as a biomarker to improve staging accuracy and guide treatment decisions in cervical cancer patients.
Pernilla Israelsson, Lisa Lif, Husam Oda, Alexandra Lorenzzi de Melo, David Lindquist, Håkan Hedman   +5 more
wiley   +1 more source