Results 261 to 270 of about 465,440 (342)

Facts, Damned Lies and Statistics: A 55 Year Stumbling Block

, 2012
John M. Rudy
openalex   +1 more source

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source

Ligand non-competitive GITR antibody prevents formation of the obligatory signal-triggering GITRL: GITR stoichiometry. [PDF]

Sci Rep
Yan J, Min-DeBartolo J, Huang CS, Sharif MN, Li L, Fish S, Dower C, Murphy D, Andreyeva T, Liu H, Han X, Zheng W, Ooi JH, Edmonds J, Chen T, Maben Z, Stevens CR, Goihberg P, Nocula-Lugowska M, Evans SM, Mosyak L, Kelleher K, Dickinson C, Hegen M, Winkler A, Karlsson F.   +25 more
europepmc   +1 more source

Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants

Annals of Clinical and Translational Neurology, EarlyView.
Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants. ABSTRACT Objective Return of disease activity is expected when patients discontinue disease‐modifying therapy (DMT) for multiple sclerosis (MS). Some MS DMTs are associated with higher‐than‐expected disease activity (rebound) after discontinuation.
Ralf Gold, Krzysztof W. Selmaj, Regina Berkovich, Jeffrey A. Cohen, Giancarlo Comi, Eva K. Havrdová, James K. Sheffield, Hetal Desai, Chun‐Yen Cheng, Jon V. Riolo, Andrew Thorpe, Erik DeBoer, Bruce A. C. Cree   +12 more
wiley   +1 more source

How thoughtful experimental design can empower biologists in the omics era. [PDF]

Nat Commun
Wagner MR, Kleiner M.
europepmc   +1 more source

S1 Text Table A. Previous health oriented indices for risk due to climate change in LMICs using IPCC frameworks. S1 Text Table B. Selected variables for risk index. S1 Text Table C. Summary statistics of variables included in the risk index. S1 Text Table D. Risk of diarrheal disease for each sub-county by county in the Lake Victoria region block of Kenya [42–50].

Megan Kowalcyk (19785948), Honghyok Kim (9939619), Aloyce Odhiambo Rakinyo (22022151), Samuel Dorevitch (1802782)   +3 more
openalex   +1 more source

ALDOA Promotes Glycolysis and NLRP3/GSDMD Pyroptosis to Accelerate ALS Progression

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron degeneration. Glycolytic dysregulation is implicated in disease progression, yet the underlying mechanisms remain unclear. This study investigates how Aldolase A (ALDOA) drives ALS progression through glycolysis‐mediated motor neuron pyroptosis.
Kaixin Yan, Yan Jiang, Yuxuan Yong, Tianshuo Zhang, Niannian Zhang, Qianqian Zeng, Xue Gong, Li Meng, Fangfang Bi, Yongmin Liu   +9 more
wiley   +1 more source

B-cell abundance in perivascular cuffs associates with local lesion activity in multiple sclerosis. [PDF]

Acta Neuropathol Commun
Engelenburg HJ, Westenbrink E, Runderkamp E, Marques AM, van Luijn MM, Hsiao CC, Huitinga I, Hamann J, Smolders J.   +8 more
europepmc   +1 more source

ASYMPTOTIC EQUIVALENCE OF STATISTICAL INFERENCE BASED ON ALIGNED RANKS AND ON WITHIN-BLOCK RANKS(Asymptotic Methods of Statistics)

, 1988
Taka-aki Shiraishi
openalex   +1 more source

Preferences for post‐traumatic osteoarthritis prevention strategies in individuals with anterior cruciate ligament injury

Arthritis Care &Research, Accepted Article.
Objectives There is growing interest in evaluating new strategies to delay or prevent post‐traumatic osteoarthritis (PTOA) in individuals who have sustained anterior cruciate ligament (ACL) injury. This study sought to determine characteristics of potential treatments that are acceptable to patients with ACL injury.
Kevin Kennedy, Lily Waddell, Adam Easterbrook, Jeffrey N. Katz, Cale Jacobs, Morgan Jones, Faith Selzer, Elena Losina, Liana Fraenkel, Nick Bansback   +9 more
wiley   +1 more source