The prodrug strategy used in this study offers new promise for cancer metabolism‐based therapies. JHU083, a prodrug that, when cleaved by protease in the tumor microenvironment, yields the glutamine antagonist DON. JHU083 inhibits tumor growth by targeting glutamine‐addicted cancer cells and suppressing glutamine‐dependent M2 macrophages, leading to a ...
Tianhe Li+10 more
wiley +1 more source
An oversampling-undersampling strategy for large-scale data linkage. [PDF]
Hassani H+4 more
europepmc +1 more source
HMGB1 derived from the pyroptotic environment in Hirschsprung‐associated enterocolitis mediates the formation of macrophage extracellular traps through TLR4 ‐p38 MAPK/p65 NF‐kB signaling pathways. Macrophage extracellular traps induce increased ROS production and pyroptosis of colonic epithelial cells.
Rui Zhang+6 more
wiley +1 more source
Intraoperative Nerve Monitoring in Thyroid Surgery: A Comprehensive Review of Technical Principles, Anesthetic Considerations, and Clinical Applications. [PDF]
Jung JY.
europepmc +1 more source
Fecal Microbiota Transplantation Modulates Th17/Treg Balance via JAK/STAT Pathway in ARDS Rats
Fecal microbiota transplantation (FMT) alleviates lung and intestinal injury in lipopolysaccharide (LPS)‐induced acute respiratory distress syndrome (ARDS) in rats. This study demonstrates that FMT restores the balance between Th17 and Treg cells, inhibits the JAK/STAT pathway, and modulates cytokine levels, reducing inflammation and lung damage. These
Dongwei Zhang+8 more
wiley +1 more source
Epicardial VEGFC/D signaling is essential for coronary lymphangiogenesis. [PDF]
de la Cruz E+4 more
europepmc +1 more source
TIM3-Mediated Differentiation of IL-10-Producing CD25+ B Cells by Expanded Regulatory T Cells
Alhabbab RY+3 more
europepmc +1 more source
Higher education expansion and individual health improvement: concurrent discussion of the blocking effect on the intergenerational transmission of health. [PDF]
Chu Y, Chen S, Zhang L.
europepmc +1 more source
Serotonin neuromodulation directs optic nerve regeneration. [PDF]
Saied-Santiago K+3 more
europepmc +1 more source
Wolbachia enhances the survival of Drosophila infected with fungal pathogens. [PDF]
Perlmutter JI+3 more
europepmc +1 more source