Results 21 to 30 of about 706,861 (226)

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

Atmospheric blocking and mean biases in climate models [PDF]

, 2010
Models often underestimate blocking in the Atlantic and Pacific basins and this can lead to errors in both weather and climate predictions. Horizontal resolution is often cited as the main culprit for blocking errors due to poorly resolved small-scale ...
Hinton, Tim, Knight, Jeff, Martin, Gill, Scaife, Adam A., Woollings, Tim   +4 more
core   +1 more source

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

A Constraint on the x Dependence of the Light Antiquarks Ratio [PDF]

, 2002
We perform a careful study on the effect of the Pauli blocking to the light antiquark structure of the proton sea. We develop the formal expressions for the antiquark distributions, highlighting the role played by quark statistics and the vacuum ...
Steffens, F M
core   +2 more sources

Asymptotic expansions for blocks estimators: PoT framework [PDF]

arXiv, 2023
We consider disjoint and sliding blocks estimators of cluster indices for multivariate, regularly varying time series in the Peak-over-Threshold framework. We aim to provide a complete description of the limiting behaviour of these estimators. This is achieved by a precise expansion for the difference between the sliding and the disjoint blocks ...
arxiv  

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source

The elusive nature of the blocking effect: 15 failures to replicate [PDF]

, 2016
With the discovery of the blocking effect, learning theory took a huge leap forward, because blocking provided a crucial clue that surprise is what drives learning.
Alfei, Joaquín Matías, Beckers, Tom, Boddez, Yannick, D'Hooge, Rudi, De Houwer, Jan, Krypotos, Angelos-Miltiadis, Maes, Elisa   +6 more
core   +2 more sources

Spectral Statistics of Sample Block Correlation Matrices [PDF]

arXiv, 2022
A fundamental concept in multivariate statistics, sample correlation matrix, is often used to infer the correlation/dependence structure among random variables, when the population mean and covariance are unknown. A natural block extension of it, {\it sample block correlation matrix}, is proposed to take on the same role, when random variables are ...
arxiv  

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

Asymptotic expansions for sums of block-variables under weak dependence [PDF]

Annals of Statistics 2007, Vol. 35, No. 3, 1324-1350, 2006
Let $\{X_i\}_{i=-\infty}^{\infty}$ be a sequence of random vectors and $Y_{in}=f_{in}(\mathcal{X}_{i,\ell})$ be zero mean block-variables where $\mathcal{X}_{i,\ell}=(X_i,...,X_{i+\ell-1}),i\geq 1$, are overlapping blocks of length $\ell$ and where $f_{in}$ are Borel measurable functions.
arxiv   +1 more source