Results 41 to 50 of about 174,644 (291)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

A novel model fitted to multiple life stages of malaria for assessing efficacy of transmission-blocking interventions

Malaria Journal, 2017
Background Transmission-blocking interventions (TBIs) aim to eliminate malaria by reducing transmission of the parasite between the host and the invertebrate vector.
Ellie Sherrard-Smith, Thomas S. Churcher, Leanna M. Upton, Katarzyna A. Sala, Sara E. Zakutansky, Hannah C. Slater, Andrew M. Blagborough, Michael Betancourt   +7 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

SNPAnalyzer 2.0: A web-based integrated workbench for linkage disequilibrium analysis and association analysis

BMC Bioinformatics, 2008
Background Since the completion of the HapMap project, huge numbers of individual genotypes have been generated from many kinds of laboratories. The efforts of finding or interpreting genetic association between disease and SNPs/haplotypes have been on ...
Kim Yujung, Lee Youngbok, Yoo Jinho, Rha Sun, Kim Yangseok   +4 more
doaj   +1 more source

Emergent Pauli Blocking in a Weakly Interacting Bose Gas

Physical Review X, 2022
The relationship between many-body interactions and dimensionality is integral to numerous emergent quantum phenomena. A striking example is the Bose gas, which upon confinement to one dimension (1D) obeys an infinite set of conservation laws ...
Federica Cataldini, Frederik Møller, Mohammadamin Tajik, João Sabino, Si-Cong Ji, Igor Mazets, Thomas Schweigler, Bernhard Rauer, Jörg Schmiedmayer   +8 more
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Move-stop-move Target Tracking with Low-altitude Surveillance Radars

Leida xuebao, 2022
Low-altitude small targets, represented by rotor unmanned aerial vehicles, always adopt slow move-and-stop strategy or employ an obstacle blocking strategy to avoid radar detection and conduct point-and-point strikes or interference on important ...
Kaiming XU, Bailu WANG, Suqi LI, Yunkai DENG, Jinghe WANG   +4 more
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

TO THE QUESTION OF PROVIDING THE CORRECT WORK OF DEVICES OF AUTOMATIC FREQUENCY DISCHARGE IN THE KUZBAS ENERGY SYSTEM

Известия высших учебных заведений: Проблемы энергетики, 2018
The article presents the statistics of false alarms of automatic frequency unloading devices for 2012-2016. An analysis of the types of automatic frequency unloading devices operated in the Kuzbass power system is also presented.
F. S. Nepsha, A. I. Glushkova, D. Yu. Vorobyеva   +2 more
doaj   +1 more source