Implication of Hyperhomocysteinemia in Blood Retinal Barrier (BRB) Dysfunction [PDF]
Biomolecules, 2020 Elevated plasma homocysteine (Hcy) level, known as hyperhomocysteinemia (HHcy) has been linked to different systemic and neurological diseases, well-known as a risk factor for systemic atherosclerosis and cardiovascular disease (CVD) and has been ...
Amany Tawfik +3 more
doaj +5 more sources
Plastic roles of pericytes in the blood–retinal barrier [PDF]
Nature Communications, 2017 Blood-retinal barrier (BRB) is composed of tightly connected endothelium and supporting pericytes and glia. Here, the authors show that pericytes are crucial for BRB buildup during retinal development and its maintenance in adult retinas in response to ...
Do Young Park +13 more
doaj +5 more sources
Microglia: The breakthrough to treat neovascularization and repair blood-retinal barrier in retinopathy [PDF]
Frontiers in Molecular Neuroscience, 2023 Microglia are the primary resident retinal macrophages that monitor neuronal activity in real-time and facilitate angiogenesis during retinal development. In certain retinal diseases, the activated microglia promote retinal angiogenesis in hypoxia stress
Xuefei Fu +7 more
doaj +2 more sources
A new perspective on protecting the blood-retinal barrier against injury in diabetic retinopathy: mitophagy [PDF]
Frontiers in EndocrinologyThe blood-retinal barrier (BRB) comprises the inner blood-retinal barrier (iBRB) and the outer blood-retinal barrier (oBRB). The integrity of the BRB is essential to maintaining stability of the retinal microenvironment. Mitophagy plays a crucial role in
Mengtian Li +7 more
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The Calcium Signalling Profile of the Inner Blood–Retinal Barrier in Diabetic Retinopathy [PDF]
CellsDiabetic retinopathy is a sight-threatening complication of diabetes mellitus, affecting millions of people worldwide. From a vascular perspective, diabetic retinopathy compromises the structure and function of the blood–retinal barrier, leading to ...
Francesco Moccia, Silvia Dragoni
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Cholinergic neural activity directs retinal layer-specific angiogenesis and blood retinal barrier formation [PDF]
Nature Communications, 2019 During retinal development, waves of cholinergic neural activity play a role in retinal circuit development. Here, the authors show that this activity also contributes to layer-specific angiogenesis and formation of the blood-retinal barrier.
G. A. Weiner +8 more
doaj +3 more sources
Chronic dental lighting disrupts blood-retinal barrier homeostasis via vascular and inflammatory pathways [PDF]
International Journal of Oral ScienceExcessive lighting is integral to dentists’ daily routines but can impair their vision, affecting personal and professional performance. Most studies focus on acute photodamage, neglecting chronic photo-injury from dental lighting and its impact on the ...
Haiyang Sun +12 more
doaj +2 more sources
Current research into brain barriers and the delivery of therapeutics for neurological diseases: a report on CNS barrier congress London, UK, 2017 [PDF]
Fluids and Barriers of the CNS, 2017 This is a report on the CNS barrier congress held in London, UK, March 22–23rd 2017 and sponsored by Kisaco Research Ltd. The two 1-day sessions were chaired by John Greenwood and Margareta Hammarlund-Udenaes, respectively, and each session ended with a ...
John Greenwood +14 more
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Wnt Signaling in Inner Blood-Retinal Barrier Maintenance. [PDF]
Int J Mol Sci, 2021 The retina is a light-sensing ocular tissue that sends information to the brain to enable vision. The blood–retinal barrier (BRB) contributes to maintaining homeostasis in the retinal microenvironment by selectively regulating flux of molecules between systemic circulation and the retina.
Yemanyi F +4 more
europepmc +4 more sources
Preserving blood-retinal barrier integrity: a path to retinal ganglion cell protection in glaucoma and traumatic optic neuropathy [PDF]
Cell RegenerationRetinal ganglion cells (RGCs) are the visual gateway of the brain, with their axons converging to form the optic nerve, making them the most vulnerable target in diseases such as glaucoma and traumatic optic neuropathy (TON).
Lai-Yang Zhou +5 more
doaj +2 more sources