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THE BLOOD‐RETINAL BARRIER PERMEABILITY IN ESSENTIAL HYPERTENSION
Acta Ophthalmologica, 1983In a series of 8 patients with recently discovered moderate essential hypertension the blood‐retinal barrier permeability to fluorescein was determined by aid of quantitative vitreous fluorophotometry before and after normalization of the systemic blood pressure.
B, Krogsaa +3 more
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The inner blood-retinal barrier in diabetes
Graefe's Archive for Clinical and Experimental Ophthalmology, 1985The inner blood-retinal barrier is highly complex, dependent on a normally functioning retinal vascular endothelium and possibly adjacent perivascular cells. There are undoubtedly many different grades of barrier failure, and in the early stages an inbuilt compensatory mechanism may prevent significant fluid accumulation and delay associated structural
D. B. Archer +2 more
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Blood-Retinal Barrier in Experimental Myopia
1998We have reviewed our previous work on the blood-retinal barrier (BRB) permeability in experimental myopia as a index of the retinal pigment epithelial function in monkeys. We conducted two separate studies. In Experiment 1, six young cynomolgus monkeys underwent monocular eyelid suturing.
Satoshi Ishiko +2 more
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The Blood-Retinal Barrier: Structure and Functional Significance
2010Formation and maintenance of the blood-retinal barrier is required for proper vision and loss of this barrier contributes to the pathology of a wide number of retinal diseases. The retina is responsible for converting visible light into the electrochemical signal interpreted by the brain as vision.
E Aaron, Runkle, David A, Antonetti
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Efflux proteins of outer blood‐retinal barrier
Acta Ophthalmologica Scandinavica, 2007Abstract Purpose: Blood‐retinal barrier (BRB) restricts movements of drugs from blood circulation to the retina. Efflux proteins of retinal pigment epithelium (RPE), which forms the outer part of BRB, may have a role in this barrier. The aim of this study was to measure efflux protein (multidrug resistance associated proteins (MRP1‐6) and breast cancer
E MANNERMAA +4 more
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2014
The subject of the blood-retinal barrier (BRB) is important in understanding the pathology of various retinal diseases as well as in their treatment. There is a voluminous literature on the BRB and its derangement. The retina is transparent so that the light travels unhindered to the photoreceptors.
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The subject of the blood-retinal barrier (BRB) is important in understanding the pathology of various retinal diseases as well as in their treatment. There is a voluminous literature on the BRB and its derangement. The retina is transparent so that the light travels unhindered to the photoreceptors.
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Astemizole reduces blood-retinal barrier leakage in experimental diabetes
Journal of Diabetes and its Complications, 1992We examined the potential of astemizole, a histamine H1-receptor antagonist that does not cross the blood-brain barrier, to reverse blood-retinal barrier leakage to albumin in streptozotocin diabetic rats. Four groups of nondiabetic and four groups of diabetic rats received vehicle or astemizole at dosages of 5, 10, or 20 mg/kg body weight for days 22 ...
T M, Hollis +4 more
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Pathology of the Blood-Retinal Barrier
1980The primary sites of the blood-retinal barrier are the endothelium of the retinal capillary and the retinal pigment epithelium (RPE). Yet, these two types of cells are very different. Embryologically, the endothelium of the retinal capillary is of mesodermal origin, but the RPE derives from neuroectoderm.
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Assessment of blood-retinal barrier integrity.
Histology and histopathology, 1995The blood-retinal barrier consists of two components which are comprised of the retinal vascular endothelium and the retinal pigment epithelium, respectively. Its functional integrity can be recognized by tight junctions between these cells with a paucity of endocytic vesicles within them and the presence of the molecules that regulate the ionic and ...
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The Mechanism of Blood-Retinal Barrier Breakdown in Diabetes
Archives of Ophthalmology, 1985Two research in the cellular mechanisms of diabetic retinopathy have been of major recent interest—the pathogenesis of the earliest functional and anatomic lesions of the disease and the pathogenesis of the retinal neovascularization that occurs in its late stages. Of these two research problems, the first is probably the most perplexing.
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