Results 51 to 60 of about 86,370 (197)

The Importance and Control of Low-Grade Inflammation Due to Damage of Cellular Barrier Systems That May Lead to Systemic Inflammation

Frontiers in Neurology, 2019
Systemic low-grade inflammation can be initiated in vivo after traumatic injury or in chronic diseases such as neurodegenerative, metabolic, and autoimmune diseases.
Cecilia Rönnbäck, Cecilia Rönnbäck, Elisabeth Hansson   +2 more
doaj   +1 more source

Evaluation of an Intravitreal Rho-Associated Kinase Inhibitor Depot Formulation in a Rat Model of Diabetic Retinopathy

Pharmaceutics, 2021
Rho-associated kinase (ROCK) activation was shown to contribute to microvascular closure, retinal hypoxia, and to retinal pigment epithelium (RPE) barrier disruption in a rat model of diabetic retinopathy.
Cecile Lebon, Heike Neubauer, Marianne Berdugo, Kimberley Delaunay, Elke Markert, Kolja Becker, Katja S. Baum-Kroker, Jürgen Prestle, Holger Fuchs, Remko A. Bakker, Francine Behar-Cohen   +10 more
doaj   +1 more source

Molecular mechanisms separating two axonal pathways during embryonic development of the avian optic tectum [PDF]

, 1991
During embryonic development of the avian optic tectum, retinal and tectobulbar axons form an orthogonal array of nerve processes. Growing axons of both tracts are transiently very closely apposed to each other. Despite this spatial proximity, axons from
Adler, Alvarado-Mallart, Bixby, Bixby, Bonhoeffer, Bonhoeffer, Boxberg, Bray, Cohen, Edelman, Elsdale, Goldberg, Goldberg, Halfter, Halfter, Halfter, Halfter, Halfter, Halfter, Halfter, Hamburger, Hankin, Harris, Haydon, Kapfhammer, Kapfhammer, Kapfhammer, Katz, Kroger, Kröger, Lagenaur, LaVail, Letourneau, Letourneau, Liesi, Linser, Mattson, McCobb, McLoon, O'Leary, Puelles, Rager, Raper, Rathjen, Rogers, Rosner, Sanes, Silver, Silver, Smalheiser, Thanos, Tomaselli, Vanselow, Walter, Wictorin, Zipser   +55 more
core   +1 more source

VEGF(164)-mediated inflammation is required for pathological, but not physiological, ischemia-induced retinal neovascularization [PDF]

, 2003
Hypoxia-induced VEGF governs both physiological retinal vascular development and pathological retinal neovascularization. In the current paper, the mechanisms of physiological and pathological neovascularization are compared and contrasted.
Adamis, AP, Amano, S, Ambati, J, D'Amore, PA, Gragoudas, ES, Hida, T, Ishida, S, Kaji, Y, Miller, JW, Ng, YS, Oguchi, Y, Ogura, Y, Shima, DT, Usui, T, Yamashiro, K   +14 more
core   +1 more source

Therapeutic blood-brain barrier modulation and stroke treatment by a bioengineered FZD4-selective WNT surrogate in mice

Nature Communications, 2023
Derangements of the blood-brain barrier (BBB) or blood-retinal barrier (BRB) occur in disorders ranging from stroke, cancer, diabetic retinopathy, and Alzheimer’s disease.
Jie Ding, Sung-Jin Lee, Lukas Vlahos, Kanako Yuki, Cara C. Rada, Vincent van Unen, Meghah Vuppalapaty, Hui Chen, Asmiti Sura, Aaron K. McCormick, Madeline Tomaske, Samira Alwahabi, Huy Nguyen, William Nowatzke, Lily Kim, Lisa Kelly, Douglas Vollrath, Andrea Califano, Wen-Chen Yeh, Yang Li, Calvin J. Kuo   +20 more
doaj   +1 more source

Soluble Epoxide Hydrolase Inhibition for Ocular Diseases: Vision for the Future [PDF]

, 2019
Ocular diseases cause visual impairment and blindness, imposing a devastating impact on quality of life and a substantial societal economic burden. Many such diseases lack universally effective pharmacotherapies.
Corson, Timothy W., Park, Bomina
core   +1 more source

Functional deficits precede structural lesions in mice with high-fat diet-induced diabetic retinopathy [PDF]

, 2016
Obesity predisposes to human type 2 diabetes, the most common cause of diabetic retinopathy. To determine if high-fat diet–induced diabetes in mice can model retinal disease, we weaned mice to chow or a high-fat diet and tested the hypothesis that diet ...
Bligard, Gregory W, Lukasiewicz, Peter, Rajagopal, Rithwick, Semenkovich, Clay F, Yin, Li, Zhang, Sheng   +5 more
core   +2 more sources

Prostaglandin E2 stimulates opposing effects on inner and outer blood-retina barrier function

Frontiers in Pharmacology
IntroductionDiabetic retinopathy (DR) is the leading cause of vision loss in working-age individuals globally, and the associated complication of diabetic macular edema (DME) is the most frequent cause of vision loss in these patients.
Amy K. Stark, Anna R. Gilmartin, Cayla D. Ontko, Taylor E. Smith, Amanda L. Beall, Gary W. McCollum, John S. Penn, John S. Penn   +7 more
doaj   +1 more source

Na,K-ATPase alpha isoforms at the blood-cerebrospinal fluid-trigeminal nerve and blood-retina interfaces in the rat [PDF]

, 2013
Background: Cerebrospinal fluid (CSF) sodium concentration increases during migraine attacks, and both CSF and vitreous humor sodium increase in the rat migraine model. The Na,K-ATPase is a probable source of these sodium fluxes.
Arakaki, Xianghong, Armstrong, Brian, Chiang, Jiarong, Fonteh, Alfred N, Harrington, Michael G, Kuo, Linus, Levy, Dan, McCleary, Paige, Techy, Matthew   +8 more
core   +2 more sources

Alterations of the blood-retinal barrier and retinal thickness in preclinical retinopathy in subjects with type 2 diabetes [PDF]

, 2000
OBJECTIVE: To identify alterations of the blood-retinal barrier by mapping retinal fluorescein leakage into the vitreous and changes in retinal thickness occurring in the macular region in preclinical diabetic retinopathy.
Bernardes, RC, Cunha-Vaz, JG, Lobo, CL
core   +1 more source