Results 41 to 50 of about 3,752,555 (313)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

IDB News: Vol. 3, no. 11, December 1976

, 1976
IDB News is a monthly publication of the Inter-American Development Bank and appears in English and Spanish ...
Inter-American Development Bank
core   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Blood Donor Serological Screening in Makkah, Saudi Arabia: A 7-Year Retrospective Study on Transfusion-Transmitted Infections

International Journal of Microbiology
Conclusion: The overall prevalence of TTIs among blood donors in Makkah was low, affirming the effectiveness of current screening protocols. However, the relatively high prevalence of hepatitis B core antibodies indicates prior exposure among a notable ...
Amr J. Halawani, Afnan J. Hawsawi, Latifa A. Jaber, Saeed M. Kabrah, Turki M. Maghrabi, Khaled M. Alobaid, Alaa A. Kaki, Ayman M. Aljabri, Adel S. Alsaedi, Mohammed M. Alharbi, Abdullah F. Alhazmi, Hani A. Alsaedi, Ahmed S. Almalki, Fatima A. Alharthi, Yahya H. Almalki, Abdullah M. Alotaibi, Rakan M. Abu-Harba, Ahmad F. Arbaeen, Hesham A. Malak, Mohammad O. Sabbag, Rani O. Alnabati   +20 more
doaj   +1 more source

Serological and molecular biological analysis of RhD--: a case report

Zhongguo shuxue zazhi, 2023
Objective To study the blood group serology and molecular biology of patients with RhD--, so as to guide clinical blood use. Methods The EDTA-K2 anticoagulant blood of the patient was detected for Rh antigens and antibodies. Meanwhile, DNA was extracted,
Bo SHUI, Zhibing HOU, Li YAO, Wei YAN, Jiwu HE   +4 more
doaj   +1 more source

IDB News: Vol. 3, no. 3, April 1976

, 1976
IDB News is a monthly publication of the Inter-American Development Bank and appears in English and Spanish ...
Inter-American Development Bank
core   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Bioinformatics analysis of HBV s gene mutation in blood donor

Zhongguo shuxue zazhi
Objective To analyze the infectious indicators, HBV s gene mutations and changes in bioinformatics characteristics of HBV DNA+ /HBsAg- blood donor. Methods A sample of HBV DNA+ /HBsAg- was screened by PCR method, and HBsAg/HBsAb/HBeAg/HBeAb/HBcAb of HBV ...
Jiacheng FAN, Qing LI, Xiuli CHEN, Shixiang LIU, Ye CHEN   +4 more
doaj   +1 more source

Trend in seroprevalence of Hepatitis B virus infection among blood donors of coastal Karnataka, India

Journal of Infection in Developing Countries, 2009
Background: Hepatitis B is one of the transfusion transmissible infections. The prevalence of this infection varies across the different geographies. Noting the trend in seroprevalence is useful to assist the preventive strategies.
Karandeep Singh, Sudha Bhat, Shamee Shastry   +2 more
doaj   +1 more source

IDB News: Vol. 1, no. 3, April 1974

, 1974
IDB News is a monthly publication of the Inter-American Development Bank and appears in English and Spanish ...
Inter-American Development Bank
core   +1 more source