Results 121 to 130 of about 365,373 (345)

Targeted Inhibition of CD74+ Macrophages by Luteolin via CEBPB/P65 Signaling Ameliorates Osteoarthritis Progression

Advanced Science, EarlyView.
This study identifies CD74⁺ macrophages as key drivers of synovial inflammation in osteoarthritis (OA). The flavonoid luteolin is predicted to inhibit this pathway by blocking Nuclear Factor Kappa‐light‐chain‐enhancer of Activated B cells (NF‐κB) signaling. To enhance delivery, a targeted nanoplatform (MDSPL) is developed.
Rui Peng, Bo Yu, Lei Zhang, Zhaowen Xue, Lutian Yao, Qingjun Yang, Zitao Liu, Sizhi Wu, Yongquan Huang, Xiaofei Zheng, Huiying Guo, Songwei Huan, Tao Jiang, Huajun Wang, Yulong Wei, Tao Gui   +15 more
wiley   +1 more source

Transfusion pattern of blood products in a blood bank at a tertiary care hospital

, 2020
Jeevaraj Giridharan, Sarada V
openalex   +2 more sources

THE IMMUNE RESPONSE AGAINST RABIES VIRUS AMONG CANINE DONORS IN A ROMANIAN BLOOD BANK

, 2021
T Ionescu, Marius Dan, D. Cobzariu, Stelian Bărăităreanu, Doina Daneș   +4 more
openalex   +2 more sources

Metformin Impairs Breast Cancer Growth through the Inhibition of PRMT6

Advanced Science, EarlyView.
Metformin has a biological activity against breast cancer. However, it is largely unknown about its precise therapeutic targets. Here, histone arginine methyltransferase PRMT6 is identified as a new anti‐cancer target for metformin. Metformin directly binds PRMT6 and inhibits its ability to catalyze histone H3R2 asymmetric dimethylation (H3R2me2a ...
Yinsheng Wu, Xinlin Xu, Yue Tong, Min Wang, Feng Ge, Min Wu, Yunlong Wang, Gang Chen, Xilan Yu, Shanshan Li   +9 more
wiley   +1 more source

Effects of SARS-CoV-2 vaccination on blood donation and blood banks in India. [PDF]

Ann Med Surg (Lond), 2022
Hunain R, Uday U, Rackimuthu S, Nawaz FA, Narain K, Essar MY, Rehman MU, Ahmad S, Butt A.   +8 more
europepmc   +1 more source

Estimation of the Distribution of Random Parameters in Discrete Time Abstract Parabolic Systems with Unbounded Input and Output: Approximation and Convergence [PDF]

, 2019
A finite dimensional abstract approximation and convergence theory is developed for estimation of the distribution of random parameters in infinite dimensional discrete time linear systems with dynamics described by regularly dissipative operators and ...
Luczak, Susan E., Rosen, I. Gary, Sirlanci, Melike   +2 more
core   +1 more source

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source

Quality monitoring indicator system in blood banks of Shandong: applied in blood donation services, component preparation and blood supply process

Zhongguo shuxue zazhi
Objective To establish an effective quality indicator monitoring system, scientifically and objectively evaluate the quality management level of blood banks, and achieve continuous improvement of quality management in blood bank.
Yuqing WU, Hong ZHOU, Zhijie ZHANG, Zhiquan RONG, Xuemei LI, Zhe SONG, Shuhong ZHAO, Zhongsi YANG, Qun LIU, Lin ZHU, Xiaojuan FAN, Shuli SUN, Wei ZHANG, Jinyu HAN, Haiyan HUANG, Guangcai LIU, Ping CHEN, Xianwu AN, Hui ZHANG, Junxia REN, Xuejing LI, Chenxi YANG, Bo ZHOU, Hui YE, Mingming QIAO, Hua SHEN, Dunzhu GONGJUE, Yunlong ZHUANG   +27 more
doaj   +1 more source

Engineered Mesenchymal Stem Cell–NK Cell Complexes for Spatially Targeted and Functionally Revitalized Cancer Immunotherapy

Advanced Science, EarlyView.
IL‐15‐engineered stem cell–NK cell complexes, assembled via bioorthogonal chemistry, enable effective lung cancer immunotherapy. Abstract Natural killer (NK) cells represent a powerful immunotherapeutic strategy due to their intrinsic cytotoxicity and ability to target tumor cells independently of antigen presentation.
Qian Zhang, Bo Yin, Munaiwaier Sabier, Youlan Yang, Mengling Wu, Zhouping Zhao, Xuanzhi Luo, Yuehong Zhong, Xiuming Zhu, Jie Zhang, Jing Wang, Kai Chen, Fei Ruan, Wei Zhang, Zhimin Lu, Jiong Wang   +15 more
wiley   +1 more source

Performance of Chimeric Trypanosoma cruzi Antigens in Serological Screening for Chagas Disease in Blood Banks. [PDF]

Front Med (Lausanne), 2022
Dos Santos EF, Silva ÂAO, Freitas NEM, Leony LM, Daltro RT, Santos CAST, de Almeida MDCC, de Araújo FLV, Celedon PAF, Krieger MA, Zanchin NIT, Dos Reis MG, Santos FLN.   +12 more
europepmc   +1 more source