Results 221 to 230 of about 4,957,945 (327)

Mortalin and PINK1/Parkin‐Mediated Mitophagy Represent Ovarian Cancer‐Selective Targets for Drug Development

open access: yesAdvanced Science, EarlyView.
Ovarian cancer patients with high levels of mortalin protein in their tumors have worse survival. The investigational drug SHetA2 interferes with mortalin's support of mitochondria. The resulting mitochondrial damage causes a process called mitophagy that contributes to how SHetA2 kills cancer cells. Noncancerous cells repair their mitochondria through
Vishal Chandra   +9 more
wiley   +1 more source

Monitoring the Dynamics of Alzheimer's Disease Biomarkers and the APOE–Tau Axis via Human Cerebral Organoids with Immuno‐SERS

open access: yesAdvanced Science, EarlyView.
Noninvasive and sensitive detection of tau protein dynamics across developmental stages and APOE genotypes remain a challenge in Alzheimer's disease (AD) research. This study reveals the dynamics of tau secretion in label‐free manner using surface‐enhanced Raman spectroscopy (SERS) and human cerebral organoids (hCOs). This study provides novel insights
Yongjae Jo   +11 more
wiley   +1 more source

External Quality Program Reports of HBsAg, AntiHIV 1,2 studied in Tepecik Teaching Hospital Blood Bank

open access: bronze, 2007
Neval Ağuş   +4 more
openalex   +2 more sources

SAD_BaSe: A Blood Bank Data Analysis Software [PDF]

open access: green, 2012
Augusto Ramoa   +2 more
openalex   +1 more source

The Role of CAF‐derived Vitronectin in Promoting Colorectal Cancer Progression and Immunosuppression

open access: yesAdvanced Science, EarlyView.
Cancer‐associated fibroblast (CAF)‐derived VTN upregulates SLC6A8 expression in colorectal cancer (CRC) cells and macrophages through enhanced FAK phosphorylation. This modulation significantly increases the cellular uptake of creatine and ATP, promoting cancer progression and macrophage polarization.
Jiahua Yu   +5 more
wiley   +1 more source

Plasma Metabolic Profile with Machine Learning Reveals Distinct Diagnostic and Biological Signatures for Pathologic Myopia

open access: yesAdvanced Science, EarlyView.
Plasma metabolic detection combined with machine learning offers a precise (area under the curve of 0.874) and high‐throughput (<30 s) diagnosis for pathologic myopia (serious myopic macular degeneration). The biomarkers indicate the pathologic myopia‐associated systemic metabolic reprogramming, which exhibits specificity for myopic macular ...
Ziheng Qi   +13 more
wiley   +1 more source

Circulating Tumor Cells Shed Shearosome Extracellular Vesicles in Capillary Bifurcations That Activate Endothelial and Immune Cells

open access: yesAdvanced Science, EarlyView.
Using microfluidic models of capillary networks, this study discovered that fluid shear stresses on circulating tumor cells transiting through capillary‐sized bifurcations shed a novel class of shear‐dependent large extracellular vesicle, “shearosomes”, whose proteome comprises of over 3000 distinct proteins.
Angelos Vrynas   +16 more
wiley   +1 more source

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