Results 91 to 100 of about 17,492,293 (382)

Biomechanical properties of red blood cells in health and disease towards microfluidics.

Biomicrofluidics, 2014
Red blood cells (RBCs) possess a unique capacity for undergoing cellular deformation to navigate across various human microcirculation vessels, enabling them to pass through capillaries that are smaller than their diameter and to carry out their role as ...
G. Tomaiuolo
semanticscholar   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

In-depth proteomics identifies a role for autophagy in controlling reactive oxygen species mediated endothelial permeability [PDF]

, 2016
Endothelial cells (ECs) form the inner layer of blood vessels and physically separate the blood from the surrounding tissue. To support tissues with nutrients and oxygen, the endothelial monolayer is semipermeable.
Anderson, Kurt I., Athineos, Dimitris, Blyth, Karen, Erami Rud Majani, Zahra, Neilson, Lisa, Patella, Francesca, Ryan, Kevin, Zanivan, Sara Rossana   +7 more
core   +10 more sources

Comparative diagnostic performance of imaging modalities in chronic pancreatitis: a systematic review and Bayesian network meta-analysis

BMC Medical Imaging
Purpose We aimed to perform a Bayesian network meta-analysis to assess the comparative diagnostic performance of different imaging modalities in chronic pancreatitis(CP).
Ping Yu, Xujia Zhou, Li Yue, Ling Zhang, Yuan Zhou, Fei Jiang   +5 more
doaj   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Pvr expression regulators in equilibrium signal control and maintenance of Drosophila blood progenitors. [PDF]

, 2014
Blood progenitors within the lymph gland, a larval organ that supports hematopoiesis in Drosophila melanogaster, are maintained by integrating signals emanating from niche-like cells and those from differentiating blood cells.
Banerjee, Utpal, Evans, Cory J, Mondal, Bama Charan, Shim, Jiwon   +3 more
core   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

T helper cell subsets specific for pseudomonas aeruginosa in healthy individuals and patients with cystic fibrosis [PDF]

, 2014
Background: We set out to determine the magnitude of antigen-specific memory T helper cell responses to Pseudomonas aeruginosa in healthy humans and patients with cystic fibrosis.
AJ Vallis, AL Gurney, B Stockinger, BJ Stoodley, CE Zielinski, DG Downey, Dominik Hartl, EV Acosta-Rodriguez, F Ratjen, GF Sonnenberg, GF Sonnenberg, Gordon MacGregor, GP Priebe, Hannah K. Bayes, HL Tan, K Chen, K Wolk, L Martinez-Solano, M Brodlie, M Wuthrich, N Ota, N Rieber, PJ Dubin, R Basu, RB Markham, RG Wunderink, RT Sadikot, S Eyerich, S Trifari, SJ Aujla, SL Gaffen, SM Rowe, Stephen Bicknell, T Duhen, T Sawa, Tom J. Evans, Y Zheng   +36 more
core   +3 more sources

Separation of blood cells with differing deformability using deterministic lateral displacement†

Interface Focus, 2014
Determining cell mechanical properties is increasingly recognized as a marker-free way to characterize and separate biological cells. This emerging realization has led to the development of a plethora of appropriate measurement techniques. Here, we use a
D. Holmes, G. Whyte, J. Bailey, Nuria Vergara-Irigaray, Andrew E. Ekpenyong, J. Guck, T. Duke   +6 more
semanticscholar   +1 more source

The adaptability of red blood cells [PDF]

Cardiovascular Diabetology, 2013
The most important function of red blood cells (RBCs) is the carrying of oxygen, but they are also involved in inflammatory processes and during coagulation. RBCs are extremely deformable and elastic, as they are exposed to shear forces as they travel through the vascular system.
openaire   +4 more sources