Results 121 to 130 of about 9,259,664 (317)

Release of anandamide from blood cells [PDF]

, 2006
Background: Endogenous ligands of cannabinoid receptors ( endocannabinoids), in particular anandamide ( arachidonylethanolamide), have been recognized as being of crucial importance in a variety of physiological functions.
Storr, Martin, Huber, Erasmus, Azad, Shahnaz C., Schelling, Gustav, Vogeser, Michael, Hauer, Daniela   +5 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Construction and validation of a nutritional status (CONUT)-based nomogram for predicting prolonged hematological toxicity in relapsed/refractory multiple myeloma after CAR-T cell therapy

Frontiers in Nutrition
Background aimChimeric antigen receptor (CAR)-T cell therapy is highly effective for relapsed/refractory multiple myeloma (R/R MM). Prolonged hematological toxicity (PHT) is a significant adverse event that adversely affects patient outcomes; however ...
Peng Xu, Peng Xu, Peng Xu, Xin-Ying Duan, Xin-Ying Duan, Xin-Ying Duan, Qi-Wen Feng, Qi-Wen Feng, Qi-Wen Feng, Ya-Wen Wang, Ya-Wen Wang, Ya-Wen Wang, Yang Liu, Yang Liu, Yang Liu, Huan-Xin Zhang, Huan-Xin Zhang, Huan-Xin Zhang, Kun-Ming Qi, Kun-Ming Qi, Kun-Ming Qi, Zhen-Yu Li, Zhen-Yu Li, Zhen-Yu Li, Qing-Yun Wu, Qing-Yun Wu, Qing-Yun Wu   +26 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

U-shaped association of the stress hyperglycemia ratio with all-cause mortality and premature death in patients with cardiovascular disease: a cohort study

Diabetology & Metabolic Syndrome
Background The stress hyperglycemia ratio (SHR) is recognized as a significant indicator of relative hyperglycemia that has demonstrated to correlate with poor outcomes, including elevated mortality rates in individuals facing severe acute conditions ...
Na Wang, Ya Shao, Yan Zhan, Meiling Shao, Bin Liu, Longti Li, Huiqin Zhong   +6 more
doaj   +1 more source

The impact of antibiotic use on outcomes of relapsed/refractory multiple myeloma patients treated with CAR-T therapy

Frontiers in Immunology
BackgroundIn recent years, chimeric antigen receptor (CAR)-T cell therapy has achieved tremendous efficacy in relapsed/refractory multiple myeloma (R/R MM).
Lingling Yin, Lingling Yin, Lingling Yin, Bin Lv, Bin Lv, Jiao Ge, Yuekun Qi, Yuekun Qi, Yuekun Qi, Jieyun Xia, Jieyun Xia, Jieyun Xia, Sha Ma, Sha Ma, Sha Ma, Ying Wang, Ying Wang, Ying Wang, Yang Liu, Yang Liu, Yang Liu, Dian Zhou, Dian Zhou, Dian Zhou, Jiang Cao, Jiang Cao, Jiang Cao, Zhiling Yan, Zhiling Yan, Zhiling Yan, Kunming Qi, Kunming Qi, Kunming Qi, Wei Sang, Wei Sang, Wei Sang, Depeng Li, Depeng Li, Depeng Li, Hai Cheng, Hai Cheng, Hai Cheng, Wei Chen, Wei Chen, Wei Chen, Kailin Xu, Kailin Xu, Kailin Xu, Weiying Gu, Zhenyu Li, Zhenyu Li, Zhenyu Li, Feng Zhu, Feng Zhu, Feng Zhu   +54 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Case report: A case of malignant phyllodes tumor of the breast with concurrent epithelial malignancy and heterologous chondrosarcomatous differentiation

Frontiers in Oncology
The presence of malignant heterologous elements and malignant transformation of the epithelial component in phyllodes tumor (PT) is infrequent. The co-existence of both features within a single malignant PT is exceptionally rare and poorly documented. We
Jie Yuan, Hua Zhang, Jun Huang, Bei Wang, Geng Wang, Li Yang   +5 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Donor mesenchymal stem cells trigger chronic graft-versus-host disease following minor antigen-mismatched bone marrow transplantation [PDF]

, 2012
Chronic graft-versus-host disease (cGVHD) is a complication after minor antigen mismatched bone marrow transplantation (BMT) characterized by an autoimmune-type reaction in various organs.
Yumi Matsuzaki, Yoko Ogawa, Shigeto Shimmura, Yo Mabuchi, Sadafumi Suzuki, Yutaka Kawakami, Shinichiro Okamoto, Hideyuki Okano, Takaaki Inaba, Satoru Morikawa, Saori Yaguchi, Kazuo Tsubota, Tomonori Yaguchi   +12 more
core