Results 61 to 70 of about 1,350,025 (338)

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

Development and validation of a GC-MS method for the detection and quantification of clotiapine in blood and urine specimens and application to a postmortem case [PDF]

, 2015
INTRODUCTION: Clotiapine is an atypical antipsychotic of the dibenzothiazepine class introduced in a few European countries since 1970, efficient in treatment-resistant schizophrenic patients.
Busardo', FRANCESCO PAOLO, Catanese, Miriam, Mannocchi, Giulio, Pantano, Flaminia, Tittarelli, Roberta, UMANI RONCHI, Federica   +5 more
core   +5 more sources

DISTINCT FEATURES OF STAGHORN NEPHROLITHIASIS IN SOUTH OF RUSSIA

Вестник урологии, 2013
A study of staghorn nephrolithiasis pathogenesis with aim of stone prevention has particular importance. Knowledge of urine stones’ chemical structure is a basic in individual metaphylaxis.
A. V. Кhasigov, M. A. Khagokov, I. I. Belousov, M. I. Kogan   +3 more
doaj   +1 more source

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

PENGARUH BERBAGAI DOSIS FILTRAT PARE (Momordicacharantia L) \ud TERHADAP KADAR GLUKOSA DARAH PADA TIKUS PUTIH (Rattus \ud norvegicus) HIPERGLIKEMIA [PDF]

, 2008
Hyperglycemic is a condition that glucose content in blood increases from normal limitation. If this situation done in one year and continue, it will cause mellitus diabetes.
WARDHANI T.K, SETIA
core  

Use of blood residue as alternative source of phosphorus in sunflower (Helianthus annuus L.) cultivation

Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2022
The aim of this work was to increase the aerial part, biometry, and yield of achenes from sunflower plants on the effect of increasing doses of blood residue, as an alternative source of phosphorus (P), in a clayey-textured red Oxisol.
L.Q. Oliveira, J.H.S. Taveira, P.B. Fernandes, C. Backes, C.M. Costa, A.J.M. Santos, A.L.C. Gurgel, A.P.P. Ribeiro, L.M. Rodrigues, A.G. Teodoro   +9 more
doaj   +1 more source

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

Wrangling environmental exposure data: guidance for getting the best information from your laboratory measurements. [PDF]

, 2019
BACKGROUND:Environmental health and exposure researchers can improve the quality and interpretation of their chemical measurement data, avoid spurious results, and improve analytical protocols for new chemicals by closely examining lab and field quality ...
Dodson, Robin E, Perovich, Laura J, Rudel, Ruthann A, Udesky, Julia O   +3 more
core   +1 more source

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source