Rethinking Extracellular Vesicle Signaling
Extracellular vesicles enable cell communication beyond intracellular cargo delivery. This perspective highlights two plausible surface‐based signaling modes: “bind‐and‐stay” and “bind‐and‐leave.” Transient binding to multiple cells challenges the one‐vesicle‐one‐cell model.
Wojciech Chrzanowski, Joy Wolfram
wiley +1 more source
Development and internal validation of a multimodal nomogram integrating clinical, imaging, and laboratory data to predict malignant brain edema after reperfusion in acute ischemic stroke. [PDF]
Gong W, Xia H, Chu S, Zhang J.
europepmc +1 more source
Lipid drug carriers to which ultra‐small gold nanoparticles were added enabled more efficient radiotherapy of cultured pancreatic cancer tumors. These nanoparticles boosted radiation‐induced damage to tumors by generating more reactive molecules, though higher gold levels are needed for strong benefits.
Nazareth Milagros Carigga Gutierrez +17 more
wiley +1 more source
Distinct clinical and inflammatory signatures in anterior vs. posterior circulation strokes. [PDF]
Ryder CH +9 more
europepmc +1 more source
Multiscale Acoustic Bubble Actuators Using Bioinspired Liquid‐Repellent Microstructures
The article presents multiscale acoustic bubble actuators using bioinspired liquid‐repellent microstructures, enabling programmable trapping, pumping, mixing, and precise flow control. Mimicking springtail microstructures, these scalable actuators (200 µm–1 mm) offer multifunctionality in all‐in‐one devices, letter‐shaped arrays, and 3D cube ...
Cem Balda Dayan +8 more
wiley +1 more source
Thrombolysis with Adjunctive Tirofiban in Acute Non-cardioembolic Posterior Circulation Ischemic Stroke: A Propensity Score-Matched Analysis. [PDF]
Yuan H +5 more
europepmc +1 more source
An all‐in‐one microfluidic platform consists of two‐layered PDMS channels integrated with a hydrogel microwell array. This platform enables flow‐driven tumor cell capture, enhanced spheroid formation within the microwells, and advective drug testing. ABSTRACT Effective cancer drug screening requires platforms that replicate the physiological complexity
Omar M. Rahman +2 more
wiley +1 more source
Phenotyping of Fontan-Associated Renal Physiology and Disease. [PDF]
van Hassel G +7 more
europepmc +1 more source
BLOC: Buildable and Linkable Organ on a Chip
We developed a “Buildable and Linkable Organ on a Chip” (BLOC) that can construct diverse microphysiological systems (MPSs). The BLOC is standardized to the same size and has one of the functions of “Culture,” “Control,” or “Analysis.” Users can freely configure various MPSs, including developing perfusion, cytotoxicity analysis, and biochemical ...
Yusuke Kimura +7 more
wiley +1 more source
Advanced perfusion strategy for renal protection in juxtarenal aortic aneurysms: a pilot study. [PDF]
Rusch M, Hoffmann G, Alasad N, Rusch R.
europepmc +1 more source

