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Red blood cell-hitchhiking chitosan nanoparticles for prolonged blood circulation time of vitamin K1
International Journal of Pharmaceutics, 2021Nanocarriers have been extensively applied for intravascular drug delivery. However, rapid clearance from circulation by mononuclear phagocyte system has limited their applications. Erythrocytes carriers are potential solutions to overcome the limitations of nanocarriers and considered to be ideal natural carriers for drug delivery because of their ...
Yuli, Wang +10 more
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Identification of the Proteins Determining the Blood Circulation Time of Nanoparticles
ACS Nano, 2023The therapeutic efficacy and adverse impacts of nanoparticles (NPs) are strongly dependent on their systemic circulation time. The corona proteins adsorbed on the NPs determine their plasma half-lives, and hence, it is crucial to identify the proteins shortening or extending their circulation time.
Marques, Cintia +9 more
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Relationship between circulation time and cerebral blood flow in cerebrovascular disease
Neuroradiology, 1972Comparing studies on regional cerebral blood flow and circulation time were performed in 150 patients with cerebral disorders caused by stenosing disease of extracranial and intracranial arterial vessels and by ischemic attacks without angiographic visible disturbances of the cerebral arteries.
H, Herrschaft, F, Gleim
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ACS Biomaterials Science & Engineering, 2018
Prolonging the circulation time (CT) of microparticles (MPs) in the blood is key for a successful microparticle-based medicinal approach to serve as drug delivery systems (DDSs). Previously, we reported that MPs that mimic the shape of red blood cells (RBCs) avoid accumulation in the spleen and lungs.
Koichiro Hayashi +5 more
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Prolonging the circulation time (CT) of microparticles (MPs) in the blood is key for a successful microparticle-based medicinal approach to serve as drug delivery systems (DDSs). Previously, we reported that MPs that mimic the shape of red blood cells (RBCs) avoid accumulation in the spleen and lungs.
Koichiro Hayashi +5 more
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The effect of zwitterionic surface content on blood circulation time of nanocapsule
Journal of Biomaterials Applications, 2020Zwitterionic modification can prolong the blood circulation time of nanocarrier in vivo, but zwitterionic content will affect the functions of nanocarrier such as enzyme-responsive and intracellular or extracellular delivery. Therefore, it is necessary to explore the relationship between the zwitterionic content and circulation time of nanocarrier so ...
Xing Han +7 more
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Behaviour of the Antithrombin Time After Extracorporeal Circulation of Blood
Thrombosis and Haemostasis, 1960SummaryThe effect on antithrombin time of equal quantities of heparin and of protamine sulfate, varies from individual to individual. There are differences in both the duration and intensity of effect. An antithrombin time which is extremely prolonged by large amounts of heparin can be restored to normal only for a few hours by protamine sulfate.
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Blood Flow: First Circulation Time-Activity Curves
2016This chapter discusses the information content of rapid serial images acquired during the first circulation of a radiopharmaceutical following intravenous injection. There are five nuclear medicine studies that routinely include first circulation images.
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Circulation Time and Renal Blood Flow in Kidney Carcinoma
1983Renal carcinomas are often highly vascular tumours. From angiographic as well as from direct pathologic examinations it is well known that some tumours show arteriovenous shunts (1,2). A rapid opacification of the renal vein is sometimes seen indicating shunt flow.
G. Lingårdh, S. O. Hietala
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Estimation of retinal blood flow by measurement of the mean circulation time
Cardiovascular Research, 1971A method is described for measuring the segmental mean circulation time and estimating the segmental flow in the human retina. Serial retinal photographs were taken after intravenous fluorescein injection and the relative concentration of fluorescein in the superior temporal artery and vein calculated from measurements of the optical density of the ...
C J, Bulpitt, C T, Dollery
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The clearance time of infused hematopoietic stem cell from the blood circulation
Transfusion and Apheresis Science, 2013There is no detailed information about the clearance time of infused hematopoietic stem cell (HSC) from the blood circulation in humans. In this prospective study, peripheral blood CD34+ cell counts were detected during the 4days period following autologous HSC transplantation in 20 patients by means of flow cytometry.
Donmez, Ayhan +7 more
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