Results 151 to 160 of about 26,639 (274)

Increased Numbers of CD4+ T‐Cells in the Hypocretin/Orexin Region of Narcolepsy Type 1

Annals of Neurology, EarlyView.
Narcolepsy type 1 (NT1) is presumed to be an autoimmune disorder caused by hypothalamic loss of hypocretin (Hcrt; orexin). In postmortem NT1 brains, we observed an 11‐fold increase of CD4+ T‐cells in the Hcrt region compared with control hypothalami, without a corresponding rise in CD8+ T‐cells.
Ling Shan, Milo Fonville, Mabel Hoekstra, Rolf Fronczek, Joost Smolders, Dick F. Swaab   +5 more
wiley   +1 more source

CNC–PNIPAM Drug Delivery System Improves Endometrial Receptivity via Natural Killer Cell Immune Tolerance in Endometriosis

Advanced NanoBiomed Research, EarlyView.
An injectable CNC–PNIPAM hydrogel is developed for intrauterine co‐delivery of levonorgestrel and botropase. This platform reprograms uterine natural killer cells toward an immune–tolerant phenotype and enhances endometrial receptivity marker expression. The results demonstrate a promising strategy to counteract endometriosis–associated infertility and
Zhou Liang, Yingjie Wang, Chenyu Bai, Pengfei Li, Xin He, Meng Ma, Xiaoying Luo, Yi Song, Yao Li, Yun Wang   +9 more
wiley   +1 more source

DESCRIPTIVE EPIDEMIOLOGY OF HEMOPHILIA AND OTHER COAGULATION DISORDERS IN MANSOURA , EGYPT

Mediterranean Journal of Hematology and Infectious Diseases, 2010
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Rasha ElAshry, Youssef Al Tonbary, Maysaa El Sayed Zaki   +2 more
doaj  

Nanomaterial‐Mediated Near‐Infrared Photothermal Neuromodulation for Neurologic Disorders

Advanced NanoBiomed Research, EarlyView.
This review summarizes how near‐infrared light activates photothermal nanomaterials to enable noninvasive neuromodulation with high spatiotemporal precision. It elucidates the underlying mechanisms, explores targeted therapeutic applications for neurological disorders, discusses integration with optogenetics and biosensors, and addresses future ...
Ting‐Ting Zeng, Yu‐Ge Wang, Ya‐Bing Zhang, Yuan‐Xin Bai, Si‐Tong Lin, Ting‐Ting Zhu, Yan‐Bo Zhou, Wei‐Tong Pan, Pan‐Miao Liu, Jian‐Jun Yang   +9 more
wiley   +1 more source

Cold Gas Plasma Induces Platelet Activation and Hemostasis in Native and Anticoagulated Human Blood

Advanced NanoBiomed Research, EarlyView.
Cold physical gas plasma induces platelet activation and hemostatic responses in native and anticoagulated human blood. Treatment efficacy depends on plasma parameters, including gas composition, distance, and exposure mode, which govern reactive species delivery and energy transfer.
Sander Bekeschus, Broder Poschkamp, Lea Miebach, Linus Hübner, Julia van der Linde   +4 more
wiley   +1 more source

Factor XIII Deficiency: A Silent Bleeder Behind a Normal Coagulation Profile. [PDF]

Clin Case Rep
Yadav R, Karki MR, Pokhrel D, Neupane A, Parajuli K, Rimal HS.   +5 more
europepmc   +1 more source

Integrated Evaluation of Contaminant Profiles, Detection Techniques, and Management Strategies for Tannery Sludge

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT This review article critically examines the environmental and health hazards of tannery sludge (TS), a complex by‐product of the leather tanning industry. TS is characterized by a diverse array of contaminants, including heavy metals like chromium, organic pollutants such as polycyclic aromatic hydrocarbons (PAHs), volatile organic compounds ...
Yashar Aryanfar, Ali Keçebaş, Soheil Hassanzadeh, Arash Nourbakhsh Sadabad, Farhan Lafta Rashid, Shabbir Ahmad, Ahmed Hendy, Hafiz M. Irfan, Shaban Mousavi Ghasemlou, Julio Blanco Fernandez, Jorge Luis Garcia Alcaraz   +10 more
wiley   +1 more source

Prolonged Neural Block After Lower-Limb Nerve Blocks in a Patient with Inherited Antithrombin III Deficiency: Implications for Regional Anesthesia. [PDF]

Local Reg Anesth
Aizawa T, Sugiura N, Sugita S.
europepmc   +1 more source

Interleukin‐5, Eosinophils, and Interleukin‐5 Pathway Inhibitors in Eosinophilic Granulomatosis With Polyangiitis

Arthritis &Rheumatology, EarlyView.
Interlukin‐5 (IL‐5) plays a crucial role in the pathogenesis of eosinophilic granulomatosis with polyangiitis (EGPA) by promoting eosinophil differentiation, activation, and survival. We present here a typical case of EGPA in which treatment with IL‐5 pathway inhibitors is prescribed, showing to be beneficial for the patient.
Alvise Berti, Christian Pagnoux
wiley   +1 more source

Single‐Cell RNA Sequencing Informs Precision Targeting of Monogenic Lupus Associated With IKZF1 Haploinsufficiency

Arthritis &Rheumatology, EarlyView.
Objective This study aimed to investigate the mechanisms of immune dysregulation in a pediatric patient with monogenic lupus driven by IKZF1 haploinsufficiency. Methods Peripheral immune cells from a patient with IKZF1 haploinsufficiency, patients with lupus with no currently known genetic mutations, and healthy controls were analyzed using single‐cell
Qi Zheng, Yejun Tan, Zhaoling Wang, Yanjie Qian, Qian Ma, Danping Shen, Meiping Lu   +6 more
wiley   +1 more source