Results 211 to 220 of about 5,986,563 (283)

Engineered Nanoplatforms Targeting Activated Hepatic Stellate Cells for Liver Fibrosis Therapy via TGF‐β Axis Inhibition and Ferroptosis Induction

Advanced Healthcare Materials, EarlyView.
FeS‐VA@lanifibranor (FVL), an activated hepatic stellate cell (aHSC)‐targeted nanoplatform comprising vitamin A‐functionalized two‐dimensional iron sulfide nanosheets and lanifibranor, is engineered for precision therapy of liver fibrosis. FVL suppresses the TGF‐β signaling pathway by inhibiting SMAD2/3 phosphorylation and induces ferroptosis in aHSCs,
Yinuo Yang, Mengyao Mu, Ke Ren, Hui Liu, Pengju Ma, Yingqi Wang, Mengmeng Zhang, Xueli Xu, Wenzhe Li, Wenshuang Gao, Xiao Sun, Qiang Zhu   +11 more
wiley   +1 more source

Exacerbated oral pyogenic granuloma in type 2 diabetes mellitus and advanced periodontitis: clinical management and pathophysiological insights: a case report. [PDF]

J Surg Case Rep
Alcaraz-Baturoni FJ, Ibarra-González JP, López-Hernández LF, Alarcón-Sánchez MA, Ortuño-Sahagún D, Heboyan A, González-Cárdenas JP, Lomelí-Martínez SM.   +7 more
europepmc   +1 more source

2‐Deoxyglucose Dendrimer‐Enabled Niclosamide Delivery to FRβ‐Expressing Macrophages Alleviates Endometriosis Progression and Associated Hyperalgesia

Advanced Healthcare Materials, EarlyView.
A folic acid (FA)‐conjugated 2‐deoxyglucose dendrimer selectively targets FRβ+ macrophages in endometriotic lesions, enabling precise intracellular delivery of niclosamide. This nonhormonal nanomedicine enhances drug solubility, provides controlled intracellular release, suppresses lesion growth, reduces inflammation and pain, and establishes FRβ ...
Anubhav Dhull, Mingxin Shi, Madeleine E. Harvey, Taylor M. Page, Rishi Sharma, Kenneth John Goody, Aqib Iqbal Dar, Nash S. Moawad, Vijay Kumar Sirohi, Paul S. Cooke, Kanako Hayashi, Anjali Sharma   +11 more
wiley   +1 more source

Patterns of blood cobalt levels after metal-on-metal total hip arthroplasty, predictors of elevated levels, and associations with clinical symptoms. [PDF]

Int Orthop
Gonzalez AI, Silvestrini N, Fournier C, Barea C, Peter R, Hoffmeyer P, Hannouche D, Lübbeke A.   +7 more
europepmc   +1 more source

Advancing Human Skin Equivalents: The Crucial Role of Neurovascular Integration

Advanced Healthcare Materials, EarlyView.
This review discusses the importance of integrating vascular and peripheral nerve systems into human skin equivalents (HSEs) to better recapitulate native skin physiology. Recent advances in vascularized, innervated, and neurovascularized HSEs are highlighted, together with emerging bioengineering strategies, current challenges, and future ...
Hao Wu, Lorenzo Moroni, Nicolas Lebonvallet, Vincent Flacher, Paul Wieringa   +4 more
wiley   +1 more source

Establishment Reference Intervals Using the Kosmic Algorithm for Hemoglobin Levels and Platelet, Red Blood Cell, and White Blood Cell Counts. [PDF]

J Clin Lab Anal
Liu C, Deng Z, Song Y, Wu W, Li Y, Yang F, Liu H, Zhang X.   +7 more
europepmc   +1 more source

Magnetically Driven Biofabrication for Tissue Engineering: From Nanoparticle Design to Mag‐ATMP Translation

Advanced Healthcare Materials, EarlyView.
Magnetically responsive nanoparticles enable remote control over biomaterials, cells, and engineered tissues. This review summarizes material design, biological safety, fabrication and actuation strategies, computational validation, and translational pathways that support the development of magnetic tissue‐engineering platforms and future magnetically ...
Konstantinos Ioannidis, Dimitrios Lefas, Maya Guilliams, Jackie Van Grootenbril, Isaak Decoene, Dimitrios Sakellariou, Bart Smeets, Stefanos Mourdikoudis, Ioannis Papantoniou   +8 more
wiley   +1 more source

Hemovigilance in a Brazilian Amazon blood center: A temporal analysis of 5-year consumption patterns. [PDF]

Hematol Transfus Cell Ther
Cascaes CHA, Alves TR, Campelo JAC, de Lima TA, Cristino JS, Silva-Junior AL, Cardoso EC.   +6 more
europepmc   +1 more source

Optical Detection of Cellular Signals at Material Interfaces

Advanced Healthcare Materials, EarlyView.
Emerging functional materials are transforming optical detection of cellular signals. This review highlights optical techniques that exploit the unique optical properties of diverse materials to detect and quantify cellular electrical, chemical, and mechanical signals, and discusses key opportunities and challenges.
Xuchen Ren, Jitong Ren, Zixin Zhang, Koney Eungkon Kim, Francis L. Hong, Yuecheng Peter Zhou   +5 more
wiley   +1 more source

Characterizing and mitigating cross-library PCR chimeras in Perturb-seq using Perturb-Audit. [PDF]

Blood Sci
Song X, Lu J, Zhu P.
europepmc   +1 more source