Serum Free Light Chains Removal by HFR Hemodiafiltration in Patients with Multiple Myeloma and Acute Kidney Injury. a Case Series [PDF]
, 2018 Background/Aims: Multiple myeloma (MM) represents 10% of all haematologic malignancies. Renal involvement occurs in 50% of MM patients; of them, 12-20% have acute kidney injury (AKI), with 10% needing dialysis at presentation. While hemodialysis (HD) has
Antolino, Giusy +7 more
core +2 more sources
Leukodepleted blood components do not remove the potential for long-term transfusion-associated microchimerism in Australian major trauma patients [PDF]
Chimerism, 2014 Despite the introduction of leukodepleted blood components, it has been shown that donor leukocyte engraftment (microchimerism) remains a long-term consequence of red blood cell (RBC) transfusion. The incidence of microchimerism may be affected by international disparities in blood processing methods or variations in transfusion practices.
Rena, Hirani +4 more
openaire +2 more sources
RNA-Seq optimization with eQTL gold standards. [PDF]
, 2013 BackgroundRNA-Sequencing (RNA-Seq) experiments have been optimized for library preparation, mapping, and gene expression estimation. These methods, however, have revealed weaknesses in the next stages of analysis of differential expression, with results ...
Arking, Dan E +5 more
core +2 more sources
Clinical Case Reports, 2023 Key Clinical Message Proton pump inhibitors (PPIs) are commonly used in the clinical treatment of abnormal gastric acid secretion and gastric acid related diseases.
Zhen Wang, Jun Shen, Lei Zhang
doaj +1 more source
Association between amylin and amyloid-β peptides in plasma in the context of apolipoprotein E4 allele. [PDF]
PLoS ONE, 2014 Amylin, a pancreatic peptide that readily crosses the blood brain barrier (BBB), and amyloid-beta peptide (Aβ), the main component of amyloid plaques and a major component of Alzheimer's disease (AD) pathology in the brain, share several features.
Wei Qiao Qiu +5 more
doaj +1 more source
F1000Research, 2018 Background: Large protein aggregates, known as circulating immune complexes (CICs), are formed in biological fluids as a result of the development of the body's immune response to various provoking factors.
Sergej B. Landa +3 more
doaj +1 more source
Enhanced Characterization of Drug Metabolism and the Influence of the Intestinal Microbiome: A Pharmacokinetic, Microbiome, and Untargeted Metabolomics Study. [PDF]
, 2020 Determining factors that contribute to interindividual and intra-individual variability in pharmacokinetics (PKs) and drug metabolism is essential for the optimal use of drugs in humans.
Alhaja, Maher +8 more
core +1 more source
Population genetics of trypanosoma brucei rhodesiense: clonality and diversity within and between foci [PDF]
, 2013 African trypanosomes are unusual among pathogenic protozoa in that they can undergo their complete morphological life cycle in the tsetse fly vector with mating as a non-obligatory part of this development.
A MacLeod +70 more
core +11 more sources
Visualization and Correction of Automated Segmentation, Tracking and Lineaging from 5-D Stem Cell Image Sequences [PDF]
, 2014 Results: We present an application that enables the quantitative analysis of multichannel 5-D (x, y, z, t, channel) and large montage confocal fluorescence microscopy images.
Bjornsson, Chris +7 more
core +2 more sources
Why implement universal leukoreduction?
Hematology/Oncology and Stem Cell Therapy, 2008 The improvement of transfusion medicine technology is an ongoing process primarily directed at increasing the safety of allogeneic blood component transfusions for recipients.
Wafaa Y. Bassuni +2 more
doaj +1 more source