Results 71 to 80 of about 112,813 (357)

Parabiosis, Assembloids, Organoids (PAO)

Advanced Science, EarlyView.
This review evaluates parabiosis, organoids, and assembloids as complementary disease models spanning systemic, organ, and multi‐organ levels. It highlights their construction strategies, applications, and current limitations, while emphasizing their integration with frontier technologies such as artificial intelligence, organ‐on‐a‐chip, CRISPR, and ...
Yang Hong, Lavonda Li, Lijie Yan, Long Bai, Jiacan Su, Xingcai Zhang   +5 more
wiley   +1 more source

Blood component therapy: Which, when and how much

Journal of Anaesthesiology Clinical Pharmacology, 2011
Blood transfusion refers to the perioperative administration of blood and blood components. Adherence to proper indications for blood component therapy is essential because of its potential adverse effects and costs of transfusion.
Rajesh Chand Arya, G S Wander, Pankaj Gupta   +2 more
doaj   +1 more source

Discovery of a Novel DNMT1 Inhibitor with Improved Efficacy in Treating β‐Thalassemia

Advanced Science, EarlyView.
Context of Research: β‐thalassemia affects millions worldwide. DNMT inhibitors are effective HbF‐inducers that benefit patients with β‐thalassemia. Existing DNMT inhibitors are not approved for β‐thalassemia treatment due to dose‐limiting toxicity.What We Find: DMT207 traps DNMT1 into helix‐kinked inactive conformation and enhances its interaction with
Yijie Shen, Jiale Wei, Shibing Tang, Dongliang Wu, Liangyi Zong, Shuyuan Ma, Qing Xiong, Ruijie Gong, Siyuan Xu, Chuxuan Peng, Qin Feng, Songchen Liu, Qitong Liu, Yuhua Ye, Quan Zhao, Cheng Luo, Peng Huang, Zhihai Li, Xiangqian Kong, Xianjiang Lan   +19 more
wiley   +1 more source

A Novel Real-Time Non-invasive Hemoglobin Level Detection Using Video Images from Smartphone Camera [PDF]

, 2017
Hemoglobin level detection is necessary for evaluating health condition in the human. In the laboratory setting, it is detected by shining light through a small volume of blood and using a colorimetric electronic particle counting algorithm.
Adibuzzaman, Mohammad, Ahamed, Sheikh Iqbal, Ahsan, Golam Mushih Tanimul, Chu, William, Field, Joshua, Gani, Md. O., Hasan, Md Kamrul   +6 more
core   +1 more source

A Fibreoptic Endoscopic Study of Upper Gastrointestinal Bleeding at Bugando Medical Centre in Northwestern Tanzania: a Retrospective Review of 240 Cases. [PDF]

, 2012
Upper gastrointestinal (GI) bleeding is recognized as a common and potentially life-threatening abdominal emergency that needs a prompt assessment and aggressive emergency treatment.
A Elghuel, A Timraz, AB Olokoba, AG Kankaria, Anthony Liwa, C Meaden, C Zaltman, D Pateron, DA Peura, DE Elliott, DJ Cook, DJ Exon, Eliasa Mkongo, EM Vreeburg, FK Chan, G Theocharis, GS Kibiki, HC Wolfsen, HM Salih, Hyasinta Jaka, J Chasawat, J Villanueva Palacios, JA Forrest, K Aoki, K Kivkin, K Palmer, M Suba, M Urassa, Mabula D Mchembe, Mariam Mirambo, ME Van Leerdam, Mheta Koy, MJ Kaviani, MN Lakhwani, N Sarin, NK Arora, P Vlavianos, Phillipo L Chalya, Rodrick Kabangila, S Mustapha, SA Hearnshaw, T Alempijevic, TA Rockall, TA Rockall, V Balderas, Wolfgang Scheppach   +45 more
core   +2 more sources

Advanced Human Immune Cell‐Organoid Co‐Cultures for Functional Testing of Cancer Nanovaccines

Advanced Science, EarlyView.
Pancreatic ductal adenocarcinoma remains difficult to treat. We establish an organoid–immune co‐culture using patient‐derived organoids and matched T‐cells to assess cancer vaccines. A mesothelin‐targeted nanovaccine activates antigen‐specific T‐cells, increases IFN‐γ, and targets MSLN+ organoids.
Nathalia Ferreira, David Agorku, Andre Rosa, Julia Roosz, Lena Christ, Nicole Anderle, Ajinkya Kulkarni, Abir Hussein, Sana S. Sayedipour, Omar F. Luna, Tobias Legler, Philipp Ströbel, Fernando Albericio, Luis Cruz, Phillipp Beckhove, Peter Loskill, Frauke Alves, M. Andrea Markus, Fernanda Ramos‐Gomes   +18 more
wiley   +1 more source

Analisis Sistem Pelayanan Bank Darah Rumah Sakit di Rumah Sakit Daerah Dr. M. Yunus Bengkulu Tahun 2018 [PDF]

, 2018
Quality, safe blood services are available on time, can be achieved if the service runs in a closed system, where the hospital no longer submits efforts to obtain transfusion blood to the patient's family, but the entire service mechanism is carried out ...
Angraini, W. (Wulan), Febriawati, H. (Henni), Oktarianita, O. (Oktarianita)   +2 more
core  

On the crossroad between tolerance and posttransplant lymphoma. [PDF]

, 1997
The role of the Epstein-Barr virus in the development of post-transplant lymphomas is well established. However, not all lymphomas that arise in these patients contain Epstein-Barr virus, suggesting that other cofactors are involved in tumor pathogenesis.
Nalesnik, Michael A, Starzl, Thomas E
core   +1 more source

Caspase‐3/GSDME‐Mediated Trophoblast Pyroptosis and Reciprocal Macrophage Polarization Contribute to Inflammation in Early‐Onset Preeclampsia

Advanced Science, EarlyView.
In trophoblast cells, T/S (TNFα + SM164) activated caspase‐3, which cleaved GSDME to switch apoptosis to pyroptosis, causing cell swelling, membrane rupture, and release of LDH, HMGB1, IL‐1β and IL‐18. These cytokines induced pro‐inflammatory macrophage polarization, which in turn reinforced pyroptotic signaling in trophoblasts, amplifying systemic ...
Baoying Huang, Weinan Deng, Shilei Bi, Yifan Wang, Zhaowei Tu, Lijun Huang, Lili Du, Lizi Zhang, Zhoushan Feng, Wei Sun, Tengfei Liu, Julia Kzhyshkowska, Haibin Wang, Jingsi Chen, Dunjin Chen, Shuang Zhang   +15 more
wiley   +1 more source

Utilización de la sangre y sus componentes celulares Use of blood and its cellular components

Revista Cubana de Hematología, Inmunología y Hemoterapia, 2000
La terapia transfusional es una ciencia en constante renovación. En la actualidad las ventajas de la transfusión de componentes individuales han limitado el empleo de sangre total. Los parámetros clínicos y no la cifra de hemoglobina son determinantes al
Lázaro Cortina Rosales, María del Rosario López De Roux   +1 more
doaj