Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Systems biology of stored blood cells: can it help to extend the expiration date? [PDF]
Efst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinnWith increasingly stringent regulations regarding deferral and elimination of blood donors it will become increasingly important to extend the expiration date of blood ...
Paglia, Giuseppe +2 more
core +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
The effect of short term feeding with organic and conventional diets on selected immune parameters in rat [PDF]
There is currently no evidence for beneficial health impacts being associated with the consumption of organic rather than conventional foods. This preliminary study was therefore aimed at using haematological parameters, white blood cell (WBC) number and
Baranska, A. +5 more
core
Isothermal rebreathing has been proposed as an experimental technique for estimating the alveolar levels of hydrophilic volatile organic compounds (VOCs) in exhaled breath.
Amann, Anton +7 more
core +1 more source
Direct replacement of antibodies with molecularly imprinted polymer (MIP) nanoparticles in ELISA - development of a novel assay for vancomycin [PDF]
A simple and straightforward technique for coating microplate wells with molecularly imprinted polymer nanoparticles (nanoMIPs) to develop ELISA type assays is presented here for the first time.
Caygill, J. S. +7 more
core +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Genetic variation in plasma transferrins of tambaqui, Colossoma macropomum (CUVIER 1818)
Blood specimens of tambaqui, Colossoma macropomum, an Amazonian fish of commercial importance, were examined for transferrin variants by treating blood plasma specimens with rivanol before electrophoretic analyses in starch gel media.
Jamieso, A., Teixeira, A.
core
Optimizing human pulmonary perfusion measurement using an in silico model of arterial spin labeling magnetic resonance imaging. [PDF]
Arterial spin labeling (ASL) magnetic resonance imaging (MRI) is an imaging methodology that uses blood as an endogenous contrast agent to quantify flow.
Addo, Daniel A +4 more
core +1 more source
PICALM::MLLT10 translocated leukemia
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source

