Results 141 to 150 of about 1,861,719 (357)

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

open access: yesFEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang   +7 more
wiley   +1 more source

Comparison of early reactions of the blood system in rats to immobilization, the action of hypoxia and the administration of erythopoietin [PDF]

open access: yes
Three series of experiments were simultaneously carried on rats with the purpose of studying the action of different stimulants on the blood system; rats were subjected to immobilization, hypoxic hypoxia and erythropoietin administration.
Belousova, O. I.   +3 more
core   +1 more source

Impact of Blood-Count-Derived Inflammatory Markers in Psoriatic Disease Progression [PDF]

open access: gold
Oana Mirela Tiucă   +5 more
openalex   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

open access: yesFEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid   +3 more
wiley   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

open access: yesFEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani   +6 more
wiley   +1 more source

Hematology as Related to Diving Characteristics of Elaphe obsoleta, Nerodia erythrogaster, Nerodia Fasciata and Nerodia rhombifera [PDF]

open access: yes, 1979
The diving capabilities of Nerodia erythrogaster flavigaster and Nerodia fasciata confluens were investigated and the results were compared with similar studies on Nerodia rhombifera rhombifera and Elaphe obsoleta obsoleta (Baeyens et al., 1978).
Baeyens, Dennis A.   +2 more
core   +2 more sources

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