Results 161 to 170 of about 11,240,256 (401)

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

P1450: AUTOLOGOUS STEM CELL TRANSPLANTATION INDUCES HIGHER LEVEL OF EXHAUSTED T-CELLS IN DLBCL PATIENTS BEFORE LEUKAPHERESIS FOR CAR-T CELL THERAPY.

HemaSphere, 2022
M. Farina, M. Chiarini, C. Almici, A. Beghin, E. Accorsi Buttini, A. Galvagni, E. Ferrari, A. Bianchetti, F. Zuccalà, S. Piva, I. Volonghi, L. Poli, D. Moratto, A. Leoni, F. Re, K. Bosio, S. Bernardi, N. Polverelli, A. Turra, E. Morello, C. Cattaneo, A. Lanfranchi, M. Malagola, D. Brugnoni, A. Re, D. Russo   +25 more
doaj   +1 more source

Effects of heart failure on cerebral blood flow in COPD: Rest and exercise

, 2015
Mayron F. Oliveira, Maria Clara N. Alencar, Flávio F. Arbex, Aline Souza, Priscila A. Sperandio, Luiz Antônio Rodrigues Medina, Wladimir Musetti Medeiros, Daniel M. Hirai, Denis E. O’Donnell, J. Alberto Neder   +9 more
openalex   +2 more sources

Effect of cytosol viscosity on the flow behavior of red blood cell suspensions in microvessels [PDF]

, 2020
Wei Chien, Gerhard Gompper, Dmitry A. Fedosov   +2 more
openalex   +1 more source

Pioglitazone plus (−)‐epigallocatechin gallate: a novel approach to enhance osteogenic performance in aged bone marrow mesenchymal stem cells

FEBS Open Bio, EarlyView.
Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen, Jia‐Ci Jhang, Chun‐Yi Peng, Quốc Cường Nguyễn, Feng‐Huei Lin, Hung‐Ming Wu, Shankung Lin   +6 more
wiley   +1 more source

Assessment of deformation of human red blood cells in flow cytometry: measurement and simulation of bimodal forward scatter distributions

, 2019
Jonas Gienger, Hermann Groß, Volker Ost, Markus Bär, J. Neukammer   +4 more
openalex   +1 more source

Isoflurane Causes Only Minimal Increases in Coronary Blood Flow Independent of Oxygen Demand [PDF]

, 1991
Dermot Kenny, Lester T. Proctor, William T. Schmellng, John P. Kampine, David C. Warltier   +4 more
openalex   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

Immunotherapy with an antibody against CD1d modulates neuroinflammation in an α-synuclein transgenic model of Lewy body like disease

Journal of Neuroinflammation
The neuroinflammatory process in synucleinopathies of the aging population such as Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) involves microglial activation as well as infiltration of the CNS by T cells and natural killer T cells (NKTs).
Michiyo Iba, Somin Kwon, Changyoun Kim, Marcell Szabo, Liam Horan-Portelance, Maria Lopez-Ocasio, Pradeep Dagur, Cassia Overk, Robert A. Rissman, Eliezer Masliah   +9 more
doaj   +1 more source