Results 31 to 40 of about 8,563,282 (243)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Effects of Blood Flow Restriction Training: A Systematic Review [PDF]

, 2020
The purpose of this systematic review is to compare the effects of blood flow restriction training (BFRT) to traditional resistance training (RT) with regards to muscular strengthening with a consideration of pain during exercise.
Jones, Devon, Fitzhugh, David
core   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

High-Performance Sport

Deutsche Zeitschrift für Sportmedizin, 2018
Blood flow restrictionin resistance training reduces arterial blood supply. This results in increased metabolic stress in the muscles. The aim of the study was to compare the lactate concentration of acute resistance training under muscle compression at ...
Nitzsche N, Schulze R, Weigand F, Hummer N, Schulz H   +4 more
doaj   +1 more source

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

Blood flow restriction training in neurological rehabilitation: a comprehensive review

Здоров’я, спорт, реабілітація
Background and purpose Blood flow Restriction training is a new technique that promotes muscular strength and hypertrophy using low loads. It was applied in various rehabilitation fields.
Moshera Darwish, Mohamed El-Tamawy, Habiba Soubhy, Heba Khalifa, Mohamed Marzouk   +4 more
doaj   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Fetal liver blood flow distribution: role in human developmental strategy to prioritize fat deposition versus brain development [PDF]

, 2012
Among primates, human neonates have the largest brains but also the highest proportion of body fat. If placental nutrient supply is limited, the fetus faces a dilemma: should resources be allocated to brain growth, or to fat deposition for use as a ...
Crozier, SR, Sarah R. Crozier, Sian M. Robinson, Guttorm Haugen (141243), Sarah R Crozier, Kiserud, T., Hanson, M.A., Inskip, H.M., Haugen Guttorm, Nicholas C. W. Harvey, Harvey Nicholas C. W., Crozier Sarah R., Haugen, G., Hazel M. Inskip, Robinson Sian M., Crozier, S.R., Inskip, HM, Mark A. Hanson (114427), Cyrus Cooper (141250), Godfrey, Keith M., Sian M Robinson, Mark A Hanson, Cyrus Cooper, Cooper Cyrus, Lucy Davies, Harvey, NC, Hazel M. Inskip (141248), Haugen, G, Guttorm Haugen, Harvey, N.C., Godfrey Keith M., Kiserud, T, Robinson, S.M., Mark A. Hanson, Keith M Godfrey, Nicholas C W Harvey, Hanson Mark A., Torvid Kiserud, Southampton Women's Survey Study Group, Cooper, Cyrus, Davies, L, Hanson, MA, Sarah R. Crozier (141254), Keith M. Godfrey, Inskip Hazel M., Godfrey, KM, Hazel M Inskip, Sian M. Robinson (141258), Kiserud Torvid, Keith M. Godfrey (141238), Cooper, C., Robinson, SM, Davies Lucy, Cooper, C, Torvid Kiserud (141246), Lucy Davies (141261), Davies, L., Nicholas C. W. Harvey (141252)   +57 more
core   +1 more source

The effect of blood flow restriction and plyometric training methods on dynamic balance of Taekwondo athletes

Pedagogy of Physical Culture and Sports, 2020
Background and Study Aim. Taekwondo (TKD) is a combat sport emphasizing on kicking techniques and dynamic footwork. Specialized balance ability is crucial for Taekwondo practitioners.
Manolya Akin, İnci Kesilmiş
doaj   +1 more source