Results 141 to 150 of about 6,402,056 (375)

Inhibition of Glutamine Metabolism Attenuates Tumor Progression Through Remodeling of the Macrophage Immune Microenvironment

open access: yesAdvanced Biology, EarlyView.
The prodrug strategy used in this study offers new promise for cancer metabolism‐based therapies. JHU083, a prodrug that, when cleaved by protease in the tumor microenvironment, yields the glutamine antagonist DON. JHU083 inhibits tumor growth by targeting glutamine‐addicted cancer cells and suppressing glutamine‐dependent M2 macrophages, leading to a ...
Tianhe Li   +10 more
wiley   +1 more source

L-shaped association between fasting blood glucose and urea in a non-diabetic population

open access: yesFrontiers in Nutrition
BackgroundThe relationship between fasting blood glucose and urea in non-diabetic individuals is still unclear. This study aimed to evaluate the association between fasting blood glucose and urea in a non-diabetic population.MethodsData from a cohort of ...
Chenguang Wu   +8 more
doaj   +1 more source

Intersection Between Local Anesthetics and Cancer Biology: What Now? Where Are We Going?

open access: yesAdvanced Biology, EarlyView.
Local anesthetics (LAs), widely used in anesthesia, may also play a role in cancer treatment by inhibiting tumor growth, reducing metastasis, and enhancing immune responses. They modulate key pathways like AKT/mTOR and RAS/ERK while affecting angiogenesis and tumor innervation and the immune response.
Eduardo Nunez‐Rodriguez   +3 more
wiley   +1 more source

Investing in the health of the 41-60 year old : reaping the return in the 60+ population? [PDF]

open access: yes, 2016
Introduction: Ageing brings an increased burden on healthcare systems. In Malta cardiovascular disease is the main cause of morbidity and mortality accounting for approximately 40% of all deaths.
Cachia, John   +2 more
core  

The Effect of Oral Carbohydrate Solutions on the Performance of Swimmers

open access: yesAnnals of Applied Sport Science, 2014
It is well established that carbohydrate solutions can improve the performance in prolonged exercise. The aim of this study was to compare the impact of sugar and glucose solutions on exercise performance of swimmers.
Laleh Afshari   +3 more
doaj  

3D Bioprinting of Thick Adipose Tissues with Integrated Vascular Hierarchies

open access: yesAdvanced Functional Materials, Volume 35, Issue 12, March 18, 2025.
An advanced 3D bioprinting technique is used here to create thick adipose tissues with a central, vessel and extensive branching. The construct is made using alginate, gelatin and collagen‐based bioinks. Flow through the complex vessel network is demonstrated as well as its successful integration with a femoral artery following implantation in a rat ...
Idit Goldfracht   +5 more
wiley   +1 more source

Glucose metabolism in different regions of the rat brain under hypokinetic stress influence [PDF]

open access: yes
Glucose metabolism in rats kept under long term hypokinetic stress was studied in 7 brain regions. Determination was made of the regional levels of glucose, lactate, glutamate, glutamine, aspartate, gamma-aminobutyrate and the incorporation of C-14 from ...
Konitzer, K., Voigt, S.
core   +1 more source

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