Results 121 to 130 of about 234,728 (298)
Advanced Science, EarlyView.This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva +28 more
wiley +1 more source
An evaluation of the Impaired Glucose Tolerance (IGT) pilot project [PDF]
, 2009 A pilot project, developed by Bradford and Airedale Teaching PCT was designed to identify patients within general practice with impaired glucose tolerance (IGT) and refer them to public health advisor who could provide support and individually tailored ...
Kime, NH, Lowcock, D, South, J
core
NDST3‐Induced Epigenetic Reprogramming Reverses Neurodegeneration in Parkinson's Disease
Advanced Science, EarlyView.NDST3‐mediated epigenetic reprogramming revitalizes neuronal circuits in the substantia nigra and striatum to halt dopaminergic neuron degeneration and restore motor function in Parkinson's disease models. This strategy promotes neuronal maintenance and functional recovery, highlighting NDST3's therapeutic potential in neurodegenerative disorders ...
Yujung Chang +18 more
wiley +1 more source
Blood glucose self-monitoring in older adults: new approaches
Клинический разбор в общей медицинеOver the last 50 years the prevalence of Type 2 diabetes mellitus (T2DM) in older adults (>65 years) rose dramatically. Comorbidity, high risk of hypoglycemia, lack of resilience an individual care needs are additional risk factors that complicate ...
Ilya A. Barsukov , Anna A. Demina
doaj +1 more source
Investing in the health of the 41-60 year old : reaping the return in the 60+ population? [PDF]
, 2016 Introduction: Ageing brings an increased burden on healthcare systems. In Malta cardiovascular disease is the main cause of morbidity and mortality accounting for approximately 40% of all deaths.
Cachia, John +2 more
core
Advanced Science, EarlyView.Diabetic bone marrow exhibits pathological ECM hyperviscosity that activates TRPV2‐mediated Ca2⁺ influx, leading to perinuclear F‐actin disassembly, nuclear deformation, and chromatin condensation. This cytoskeletal‐nuclear decoupling suppresses osteogenic differentiation of BMSCs.
Yao Wen +8 more
wiley +1 more source
Implementation of blood glucose self-monitoring among insulin-dependent patients with type 2 diabetes in three rural districts in Rwanda: 6 months open randomised controlled trial. [PDF]
BMJ Open, 2020 Ng'ang'a L +14 more
europepmc +1 more source
Advanced Science, EarlyView.Recent advances in materials and device engineering enable continuous, real‐time monitoring of muscle activity via wearable and implantable systems. This review critically summarizes emerging technologies for tracking electrophysiological, biomechanical, and oxygenation signals, outlines fundamental principles, and highlights key challenges and ...
Zhengwei Liao +4 more
wiley +1 more source
مجله دانشگاه علوم پزشکی بیرجند, 2016 Background and Aim: Appropriate control of blood sugar delays the onset and progression of diabetes complications. Nurses have a decisive role in the education of self-care behaviors to diabetic patients, including self-monitoring of blood glucose.
Javad Esmaeilzade +2 more
doaj
Advanced Science, EarlyView.Polycarbonate nanogels enable lipid‐free delivery of anti‐MFAP‐5 siRNA into cancer‐associated fibroblasts (CAF) in hepatocellular carcinoma. In a cirrhotic murine model, this approach silences MFAP‐5, reduces fibroblast activation, and suppresses tumor growth by inhibiting NOTCH/Hes1‐driven angiogenesis. CAF‐targeted MFAP‐5 RNAi and conserved signaling
Paul Schneider +20 more
wiley +1 more source