Results 111 to 120 of about 3,676,427 (310)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Distribution of ABO-Rh(D) blood group among nursing students: A tool for female health education

Ibom Medical Journal
Background: The International Society of Blood Transfusion has documented 30 distinct blood group systems; the ABO and Rh systems are regarded as the most important blood group systems.
Adegoke AO, Amole IO, Adesina SA, Akinwumi AI, Adeleke OT, Idowu AE, Durodola AO, Olaolorun AD   +7 more
doaj   +1 more source

Use of Topical (Intra-articular) Tranexamic Acid to Minimise Blood Loss and Transfusion in Total Knee Replacement Surgery [PDF]

, 2010
Introduction Total knee replacement (TKR) is a common orthopaedic procedure, with 20-70% of patients needing 1-3 units of blood, although allogeneic transfusion is not risk free.
ALSHRYDA, SATTAR,JABER,MOHR, Alshryda, Sattar Jaber Mohr   +1 more
core  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Disruption of SMIM1 causes the Vel− blood type

EMBO Molecular Medicine, 2013
Here, we report the biochemical and genetic basis of the Vel blood group antigen, which has been a vexing mystery for decades, especially as anti‐Vel regularly causes severe haemolytic transfusion reactions.
Bryan A. Ballif, Virginie Helias, Thierry Peyrard, Cécile Menanteau, Carole Saison, Nicole Lucien, Sébastien Bourgouin, Maude Le Gall, Jean‐Pierre Cartron, Lionel Arnaud   +9 more
doaj   +1 more source

The human P-k histo-blood group antigen provides protection against HIV-1 infection

, 2009
Several human histo-blood groups are glycosphingolipids, including P/P1/P-k. Glycosphingolipids are implicated in HIV-host-cell-fusion and some bind to HIV-gp120 in vitro.
Ma, Xue-Zhong, Binnington, Beth, Olsson, Martin L, Lund, Nicole, Yahalom, Vered, Jung, Daniel, Lingwood, Clifford A., Hellberg, Åsa,, Ramkumar, Stephanie, Branch, Donald R., Olsson, Martin L,, Sakac, Darinka, Levene, Cyril, Lund University., Hellberg, Åsa   +14 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

European Society of Hypertension guidelines for blood pressure monitoring at home: a summary report of the second international consensus conference on home blood pressure monitoring

, 2008
This document summarizes the available evidence and provides recommendations on the use of home blood pressure monitoring in clinical practice and in research. It updates the previous recommendations on the same topic issued in year 2000. The main topics
Parati, G., Kario, K, Mengden, T, Waeber, B., Ruilope, L.M., Padfield, P., Staessen, Jan A., Bilo, G., de Leeuw, P., Stergiou, G S, Palatini, P., Redon, J., Mancia, G., Ohkubo, T, Shennan, A., Redon, J, Shennan, A, Asmar, R., Padfield, P, Asmar, R, Ruilope, L M, Waeber, B, O'Brien, E., Zanchetti, A., de Leeuw, P, Bilo, G, Ohkubo, T., Imai, Y., Stergiou, G.S., Lurbe, E, Zanchetti, A, Mancia, G, Manolis, A, Staessen, J A, Imai, Y, Staessen, J.A., Pickering, T., Tisler, A, Kario, K., Manolis, A., Palatini, P, Mengden, T., Revera, M, Parati, G, Pickering, T, Lurbe, E., Tisler, A., O'Brien, E, Revera, M.   +48 more
core   +1 more source