Results 71 to 80 of about 748,429 (317)
Molecular Oncology, EarlyView.CD226+CD8+ T cells express elevated levels of RUNX2, exhibit higher proliferation capacity, cytokines and cytolytic molecules expression, and migratory capacity. In contrast, CD226−CD8+ T cells display an exhausted phenotype associated with the increased expression of co‐inhibitory receptors and impaired effector functions.
Maryam Rezaeifar +4 more
wiley +1 more source
ANNCRIPS: Artificial Neural Networks for Cancer Research In Prediction & Survival [PDF]
arXiv, 2023 Prostate cancer is a prevalent malignancy among men aged 50 and older. Current diagnostic methods primarily rely on blood tests, PSA:Prostate-Specific Antigen levels, and Digital Rectal Examinations (DRE). However, these methods suffer from a significant rate of false positive results.
arxiv
Detection of Du Antigen in Rh Negative Blood Group Individuals
RADS Journal of Biological Research & Applied Science, 2013 Du is the weak expression of D antigen. The cells which are not immediately agglutinated by Anti-D sera cannot be easily classified as D negative because some of these agglutinate after addition of antiglobulin sera. This weak reactivity is termed as Du.
Naheed Afshan1
doaj
Frontiers in Immunology, 2014 The ABO blood group system is the most important blood type system in human transfusion medicine. Here, we explore the specificity of antibody recognition towards ABO blood group antigens using computational modeling and biolayer interferometry ...
Spandana eMakeneni +5 more
doaj +1 more source
Molecular Oncology, EarlyView.Pancreatic ductal adenocarcinoma (PDAC) is a disease with very poor prognosis due to therapeutic limitations. We investigated the antitumor effects of cystatin A (CSTA) in PDAC murine models. We are first to confirm that CSTA enhances T helper type 1‐mediated antitumor effects through promotion of dendritic cells and M1 macrophage activity. CSTA can be
Alessandro Nasti +8 more
wiley +1 more source
Histo-blood group antigens as mediators of infections [PDF]
Current Opinion in Structural Biology, 2017 The critical first step of a microbial infection is usually the attachment of pathogens to host cell glycans. Targets on host tissues are in particular the histo-blood group antigens (HBGAs), which are present in rich diversity in the mucus layer and on the underlying mucosa.
Heggelund, Julie E. +3 more
openaire +5 more sources
Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer
Molecular Oncology, EarlyView.mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia +17 more
wiley +1 more source
A stochastic microscopic model for the dynamics of antigenic variation [PDF]
arXiv, 2013 We present a novel model that describes the within-host evolutionary dynamics of parasites undergoing antigenic variation. The approach uses a multi-type branching process with two types of entities defined according to their relationship with the immune system: clans of resistant parasitic cells (i.e.
arxiv
Molecular Oncology, EarlyView.Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
wiley +1 more source
Modelling Within-Host Immune Response to Visceral Helminthiasis and Malaria Co-infection with Prophylaxis [PDF]
arXiv, 2011 In this paper, a co-infection of malaria and visceral helminthiasis with immune stimulation and impairment is studied. We have assumed that an individual gets malaria infection during invasion by helminths larvae. In absence of immune response, our results show that the antigens invade the blood system if the rate of red cell rupture per invading ...
arxiv