Life Factors and Melanoma: From the Macroscopic State to the Molecular Mechanism
Melanoma, an aggressive skin cancer, arises from dynamic interactions between genetic, environmental, and lifestyle factors. This review explores how age, gender, obesity, diet, exercise, smoking, alcohol, UV exposure, circadian rhythms, and medications influence melanoma risk and progression.
Hanbin Wang +4 more
wiley +1 more source
Neonatal Hemolytic Jaundice: Causes, Diagnostic Approach, and Management. [PDF]
Parastatidou S +5 more
europepmc +1 more source
A Replicable and Generalizable Neuroimaging‐Based Indicator of Pain Sensitivity Across Individuals
Humans differ in their sensitivity to pain. With six large and diverse fMRI datasets (total N = 1046), this study finds that such individual differences in pain sensitivity can be tracked by fMRI responses to painful stimuli. A highly generalizable machine learning model is further built to predict pain sensitivity across all datasets and analgesic ...
Li‐Bo Zhang +7 more
wiley +1 more source
Molecular characterization of antimicrobial resistance genes and plasmid profiles in enterobacterales isolated from urinary tract infections in rural outpatient women in Otavalo, Ecuador. [PDF]
Hernández-Alomía F +4 more
europepmc +1 more source
Machine‐learning‐directed phytochemical pair ACT/FA, administered at BDD's orthodox ratio, synergistically modulates microglial polarization via dual Nrf2/RORγt targeting to attenuate neuroinflammation and depressive behaviors. This concentration‐dependent synergism replicates the parent formula's efficacy while providing a mechanistic basis for ...
Dongjing Guo +7 more
wiley +1 more source
Lifesaving re-transplantation with liver paired exchange donor. [PDF]
Celik N, Karakas S, Akatli AN, Yilmaz S.
europepmc +1 more source
DOES G-6-PD DEFICIENCY INCREASE HEMOLYSIS IN ABO BLOOD GROUP INCOMPATIBLE NEONATES? † 1716 [PDF]
Michael Kaplan +3 more
openalex +1 more source
Integrated ‘Shield‐Spear’ Biological Patch for Fibrosis‐Free Bladder Reconstruction
Fibrosis‐free bladder reconstruction remains challenging. This study pioneers an integrated “shield‐spear” patch: The outer anionic hydrogel layer captures GATA6+ macrophages to suppress collagen overexpression, while the inner S100 aptamer‐engineered EVs target Schwann cells to downregulate the TGFβ/Smad pathway—inhibiting fibrosis with enhanced wound
Xiaoqi Wu +14 more
wiley +1 more source
Severe hyperbilirubinemia prediction in neonates using a newly developed cord blood index (Çapa index): a promising tool: A retrospective cohort pilot study. [PDF]
Aslan MT +5 more
europepmc +1 more source

