Results 91 to 100 of about 5,515,935 (398)

Blood Lipids and Human Atherosclerosis [PDF]

Circulation, 1950
The transport of cholesterol and other lipids of serum is almost wholly in the form of very large molecular complexes of these lipids with variable amounts of protein. The exact components present in the blood of a particular individual may be quantitatively described both as to character and concentration by ultracentrifugal flotation of these ...
Frank T. Lindgren, Hardin B. Jones, Thomas P. Lyon, Beverly Strisower, John W. Gofman, Harold A. Elliott   +5 more
openaire   +3 more sources

Comprehensive profiling of lncRNAs and mRNAs enriched in small extracellular vesicles for early noninvasive detection of colorectal cancer: diagnostic panel assembly and extensive validation

Molecular Oncology, EarlyView.
Small extracellular vesicles are a promising source of diagnostic molecules. We conducted a comprehensive study, including transcriptome profiling and RT‐qPCR validation on large cohorts of samples. Diagnostic panels enabling sensitive detection of colorectal cancer and precancerous lesions were established. Some molecules were differentially expressed
Petra Vychytilova‐Faltejskova, Marketa Pavlikova, Lucie Pifkova, Robin Jugas, Tana Machackova, Lenka Radova, Milana Sachlova, Renata Bartosova, Tetiana Samoilenko, Zuzana Feckova, Jana Orlickova, Erika Slamova, Elleni Ponechal Michu, Dagmar Al Tukmachi, Michaela Ruckova, Martina Vodinska, Jan Kotoucek, Tina Catela Ivkovic, Marie Boudna, Lucia Bohovicova, Teodor Stanek, Jana Halamkova, Martin Svoboda, Vladimir Prochazka, Tomas Grolich, Zdenek Kala, Ondrej Slaby   +26 more
wiley   +1 more source

Genetic insights into repurposing statins for hyperthyroidism prevention: a drug-target Mendelian randomization study

Frontiers in Endocrinology
BackgroundCurrent therapeutic measures for thyroid dysfunction are limited and often accompanied by adverse effects. The use of lipid-lowering drugs like statins has recently been associated with lower thyroid eye diseases risk.ObjectiveTo investigate ...
Anqi Huang, Anqi Huang, Xinyi Wu, Xinyi Wu, Jiaqi Lin, Jiaqi Lin, Chiju Wei, Wencan Xu   +7 more
doaj   +1 more source

Association of apolipoprotein E gene polymorphisms with blood lipids and their interaction with dietary factors

Lipids in Health and Disease, 2018
Several candidate genes have been identified in relation to lipid metabolism, and among these, lipoprotein lipase (LPL) and apolipoprotein E (APOE) gene polymorphisms are major sources of genetically determined variation in lipid concentrations.
I. Shatwan, K. Winther, B. Ellahi, P. Elwood, Y. Ben-Shlomo, I. Givens, M. Rayman, J. Lovegrove, K. S. Vimaleswaran   +8 more
semanticscholar   +1 more source

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

Dietary Re-education, Exercise Program, Performance and Body Indexes Associated with Risk Factors in Overweight/Obese Women

Journal of the International Society of Sports Nutrition, 2005
This study observed the effect of a dietary re-education plus regular physical activity on body composition, risk factors and physical test performance of sedentary overweight/obese women and to correlate these variables one with each other. Fifty women (
Marchini Julio, Fabbro Amaury, Fett Waléria, Fett Carlos   +3 more
doaj   +1 more source

Blood lipids influence DNA methylation in circulating cells

Genome Biology, 2016
BackgroundCells can be primed by external stimuli to obtain a long-term epigenetic memory. We hypothesize that long-term exposure to elevated blood lipids can prime circulating immune cells through changes in DNA methylation, a process that may ...
K. F. Dekkers, M. van Iterson, R. Slieker, M. Moed, M. Bonder, M. van Galen, H. Mei, D. Zhernakova, L. H. van den Berg, J. Deelen, J. van Dongen, D. van Heemst, A. Hofman, J. Hottenga, C. V. D. van der Kallen, C. Schalkwijk, C. Stehouwer, E. Tigchelaar, A. Uitterlinden, G. Willemsen, A. Zhernakova, L. Franke, P. ’. ’t Hoen, R. Jansen, J. V. van Meurs, D. Boomsma, C. V. van Duijn, M. V. van Greevenbroek, J. Veldink, C. Wijmenga, E. V. van Zwet, P. Slagboom, J. Jukema, B. Heijmans, B. Consortium   +34 more
semanticscholar   +1 more source

Pericytes change function depending on glioblastoma vicinity: emphasis on immune regulation

Molecular Oncology, EarlyView.
Pericytes alter their transcriptome depending on their proximity to the tumor core. In the tumor core, pericytes display a more active state with higher communication strength but with lower immune activation potential and a shift toward extracellular matrix production.
Carolina Buizza, Robert Carlsson, Coralie Gamper, Gayatri Chitale, Johan Bengzon, Gesine Paul   +5 more
wiley   +1 more source

Sex differences in the associations between birthweight and lipid levels in middle-age: findings from the 1958 British birth cohort [PDF]

, 2008
Objective To examine sex differences in birthweight–lipid associations. Methods and results Using prospectively collected data on birthweight and non-fasting lipid levels at age 44–45 y from the 1958 British birth cohort (3603 men and 3583 women ...
Cooper, R., Power, C.
core  

An overview about erythrocyte membrane [PDF]

, 2010
© 2010 – IOS Press and the authors. All rights reservedIn the sixties and seventies, erythrocytes or red blood cells (RBCs) were extensively studied. Much has been learnt particularly concerning their metabolism and gas transporter function. In the past
Oliveira, Sofia de, Saldanha, Carlota
core   +1 more source