Results 231 to 240 of about 380,645 (315)

Biocatalytic Nanoregulators Restore Joint Redox‐Immune Homeostasis in Rheumatoid Arthritis

open access: yesAdvanced Science, EarlyView.
Mesenchymal stem cell‐derived extracellular vesicles (EVs) coat ruthenium‐loaded metal‐organic frameworks (Ru@ZrMOF), creating a targeted therapeutic (Ru@ZrMOF/EVs). This platform scavenges ROS, generates oxygen, and polarizes macrophages from M1 to M2, alleviating inflammation, inhibiting pannus, promoting cartilage repair, and downregulating HIF‐1α ...
Xingheng Wang   +7 more
wiley   +1 more source

Vm–MSI: a Vancomycin–Antimicrobial Peptide Conjugate Combating Resistant Bacteria and Broadening the Antimicrobial Spectrum

open access: yesAdvanced Science, EarlyView.
A series of vancomycin‐antimicrobial peptide conjugates is synthesized and evaluated to identify the optimal combination. Vm‐MSI, selected from multiple candidates, exhibited potent activity against vancomycin‐resistant and Gram‐negative bacteria by disrupting membranes and inducing oxidative stress, thereby expanding vancomycin's antibacterial ...
Shuangyu Li   +7 more
wiley   +1 more source

Annexin A13 Protects Against Acute Kidney Injury by Inactivating TGF‐β/Smad3 Signaling

open access: yesAdvanced Science, EarlyView.
ANXA13 is negatively regulated by Smad3 and exerts its protective role in AKI by inactivating TGF‐β/Smad3 signaling and Smad3‐p21 cell cycle arrest pathway through binding to TβRI, inhibiting the interaction between TβRI and TβRII, thereby suppressing TβRI phosporylation.
Jiaxiao Li   +12 more
wiley   +1 more source

BioCNTs Mediated Delivery of Systemically Mobile Small RNAs via Leaf Spray to Control Both Tomato DNA and RNA Viruses

open access: yesAdvanced Science, EarlyView.
A carbon nanotube‐based biopesticide system (BioCNTs) enables efficient delivery and systemic movement of RNAi molecules to control major tomato viruses. By integrating shRNA and tRNA‐like structures (TLS) with BioCNTs, this green and scalable approach achieves long‐term silencing and high antiviral efficacy through simple foliar spraying.
Xuedong Liu   +7 more
wiley   +1 more source

Sabotaged Integral HSC Heterogeneity Underlies Essential Thrombocythemia Development

open access: yesAdvanced Science, EarlyView.
Single‐cell RNA sequencing (scRNA‐seq) maps how distinct driver mutations remodel hematopoietic stem cell (HSC) programs across essential thrombocythemia (ET). Comparative analysis uncovers both shared and subtype‐specific molecular signatures, identifies a triple‐negative (TN)‐associated HSC population enriched with malignant traits, and reveals the ...
Jingyuan Tong   +21 more
wiley   +1 more source

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