Results 81 to 90 of about 6,312,638 (303)

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Surgical technique for ‘ping pong’ fractures: Elevation of depressed skull fractures in neonates with no burr hole

, 2017
Aim: Depressed skull fracture is a neurosurgical emergency. Surgical treatment usually requires a sizeable scalp incision and burr hole with or without craniotomy for reduction.
Wai-Sang Poon, Chan, Danny Tat Ming, Zhu, Cannon Xian Lun, Cannon Xian-Lun Zhu, Poon, Wai Sang, Danny Tat-Ming Chan, David Yuen-Chung Chan, Chan, David Yuen Chung   +7 more
core   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

Determination of Total Blood Loss Following Oral Surgical Procedures

, 1967
Several studies have been conducted in recent years to determine blood loss associated with oral surgery. These studies were primarily concerned with the blood lost during the surgical procedure.
Werner, Peter E.
core  

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Accuracy of visually estimated blood loss in surgical sponges by members of the surgical team

, 2019
It is important that operating room personnel monitor the correct amount of blood loss during surgery in order to properly replace lost volume. The aim of this study was to investigate the accuracy of operating room personnel in visually estimating blood
Claesson Lingehall, Helena,, Olofsson, Birgitta,, Häggström, Ann-Cristin E.,, Kollberg, Sandra E.,   +3 more
core   +1 more source

Blood Loss and Transfusion Requirement in Spine Tumor Surgery: 10 Years' Experience

Global Spine Journal, 2015
Background Surgical management of spinal tumors is an essential component of the comprehensive care of patients with cancer. It is often of a prolonged duration, which makes the anticipation and replenishment of blood lost during the surgery quite ...
Naresh Kumar, Aye Sandar Zaw
doaj   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

Intraoperative Blood Loss at Different Surgical-Procedure Stages during Posterior Spinal Fusion for Idiopathic Scoliosis

, 2023
Background and Objectives: Several predictive factors have been reportedly associated with intraoperative total blood loss (TBL) during posterior spinal fusion (PSF) for idiopathic scoliosis (IS).
Wataru Saito, Kentaro Uchida, Yuji Yokozeki, Ayumu Kawakubo, Toshiyuki Nakazawa, Masashi Takaso, Takayuki Imura, Akiyoshi Kuroda, Eiki Shirasawa, Masayuki Miyagi, Tsutomu Akazawa, Yusuke Mimura, Gen Inoue, Kawakubo, Ayumu, Miyagi, Masayuki, Saito, Wataru, Kuroda, Akiyoshi, Akazawa, Tsutomu, Nakazawa, Toshiyuki, Uchida, Kentaro, Imura, Takayuki, Inoue, Gen, Yokozeki, Yuji, Shirasawa, Eiki, Mimura, Yusuke, Takaso, Masashi   +25 more
core   +1 more source