Results 101 to 110 of about 3,547,549 (313)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Leukemia-related chromosomal loss detected in hematopoietic progenitor cells of benzene-exposed workers. [PDF]

, 2012
Benzene exposure causes acute myeloid leukemia and hematotoxicity, shown as suppression of mature blood and myeloid progenitor cell numbers. As the leukemia-related aneuploidies monosomy 7 and trisomy 8 previously had been detected in the mature ...
Guo, W, Hayes, R, Hubbard, A, Ji, Z, Lan, Q, Li, G, Linet, M, McHale, C, Rappaport, S, Rothman, N, Shen, M, Smith, Martyn T., Vermeulen, R, Yin, S, Zhang, L   +14 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

INTRAOPERATIVE BLOOD LOSS IN HEAD AND NECK CANCER OPERATIONS: A RETROSPECTIVE OBSERVATIONAL STUDY IN A TERTIARY CARE SURGICAL ONCOLOGY CENTER IN CENTRAL INDIA

National Journal of Medical Research, 2020
Introduction: Head and Neck cancer surgical operations are often associated with major blood loss requiring substitution, usually by homologous blood transfusion. The goal of this study is to retrospectively examine the intraoperative blood loss for the
Sandeep Ghosh, Sanjay Desai, Vinod Dhakad, Bonny Joseph, Elroy Saldanha, Dhruv Patel   +5 more
doaj  

Efficacy of tranexamic acid on blood loss during bimaxilary osteotomy: A randomized double blind clinical trial

Saudi Journal of Anaesthesia, 2012
Background: Tranexamic acid has been used to reduce bleeding and the subsequent need for blood transfusion in many surgeries. Because orthognathic surgery can be associated with significant bleeding, this study evaluated the efficacy of prophylactic ...
Abbas Karimi, Sussan Soltani Mohammadi, Mahboobeh Hasheminasab   +2 more
doaj   +1 more source

Postpartum Blood Loss in Women Treated for Intrahepatic Cholestasis of Pregnancy [PDF]

, 2016
OBJECTIVE To evaluate postpartum blood loss in women with treated intrahepatic cholestasis of pregnancy. METHODS In a retrospective case-control study, 15,083 deliveries including 348 women with intrahepatic cholestasis of pregnancy (2.3%) were ...
Burkhardt, Tilo, Furrer, Romana, Haslinger, Christian, Schäffer, Leonhard, Winter, Katharina, Zimmermann, Roland   +5 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

An Evaluation of the Adequacy of the Liberal Transfusion Strategy in Endoscopy-Assisted Metopic, Coronal, or Sagittal Craniosynostosis Surgeries: A Retrospective Observational Study

Medicina
Background and Objectives: This study aims to evaluate the adequacy of the liberal transfusion strategy applied in patients undergoing endoscopy-assisted Metopic, Coronal, or Sagittal craniosynostosis surgery according to the Pre-Transfusion and Post ...
Turan Evran, Emrah Egemen, Barış Albuz, İsmet Çopur, Rasim Asar, Aslı Mete Yıldız, Seher İlhan, Serkan Civlan, Hülya Sungurtekin   +8 more
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Estimation of Blood Loss in Total Knee Arthroplasty with or Without Tourniquet

Pakistan Journal of Medical Research, 2020
Background: Total knee arthroplasty (TKA) is a procedure performed for end stage knee osteoarthritis to reinstate leg function, pain control and improve quality of life. The surgery, however, is associated with a substantial risk of concealed blood loss
Mansoor Ali Khan, Muhammad Amin Chinoy, Rida Mohammad Gareeb, Syed Kamran Ahmed   +3 more
doaj