Results 151 to 160 of about 11,357,100 (356)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Research opportunities in loss of red blood cell mass in space flight [PDF]

Decreases of red blood cell mass and plasma volume have been observed consistently following manned space flights. Losses of red cell mass by United States astronauts have averaged 10 to 15% (range: 2 to 21%).
Fisher, K. D., Talbot, J. M.
core   +1 more source

Alternative Procedures for Reducing Allogeneic Blood Transfusion in Elective Orthopedic Surgery [PDF]

, 2018
Perioperative blood loss is a major problem in elective orthopedic surgery. Allogeneic transfusion is the standard treatment for perioperative blood loss resulting in low postoperative hemoglobin, but it has a number of well-recognized risks ...
Kleinert, Kathrin, Nuernberg, Johannes, Theusinger, Oliver, Werner, Clément   +3 more
core  

Effect of actinomycin D, cycloheximide, and acute blood loss on ferritin synthesis in rat liver [PDF]

, 1970
J. A. Millar, R. L. C. Cumming, Jacqueline A.M. Smith, A. Goldberg   +3 more
openalex   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Loss of MBNL1 induces RNA misprocessing in the thymus and peripheral blood [PDF]

, 2020
Łukasz J. Sznajder, Marina M. Scotti, Jihae Shin, Katarzyna Taylor, Franjo Ivankovic, Curtis A. Nutter, Faaiq Aslam, S. H. Subramony, Laura P.W. Ranum, Maurice S. Swanson   +9 more
openalex   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Predicting factors for excessive intraoperative blood loss during abdominal hysterectomy for benign gynecologic diseases

Thai Journal of Obstetrics and Gynaecology, 2009
Objectives: To determine the incidence of excessive intraoperative blood loss (> 500 ml) and to examine risk factors associated with excessive blood loss during abdominal hysterectomy for benign gynecologic conditions.
Sutthinee Wiladsakdanon, Kittipat Charoenkwan   +1 more
doaj  

Rheologic properties of senescent erythrocytes: loss of surface area and volume with red blood cell age [PDF]

, 1992
RE Waugh, M Narla, CW Jackson, TJ Mueller, Tsutomu Suzuki, GL Dale   +5 more
openalex   +1 more source