Results 261 to 270 of about 7,072,300 (361)

Dissolving Microneedle for Maintaining the Integrity of HPV Virus‐Like Particles Enabling Durable Sterile Protection Across Various Mucosal Tissues

Advanced Healthcare Materials, EarlyView.
A novel dissolving microneedle platform preserves HPV virus‐like particle (VLP) immunogenicity by maintaining structural integrity, crucial for eliciting potent immune responses. Buccal administration induces robust immune response, high neutralizing antibody titers, and durable sterile protection across oral and vaginal mucosal sites.
Hyemi Kim, Inhyuk Hwang, Juhee Seo, Chaiwon Kim, In‐Jeong Choi, Miran Kang, Min‐Seok Rha, Youngjae Hong, Jooyoung Kim, Seung‐Ki Baek, Jung‐Hwan Park, Hyung‐Ju Cho, Kihyuck Kwak   +12 more
wiley   +1 more source

Association between trace metal element concentrations in human blood plasma and early MAR embryological outcomes: a couple-based prospective cohort study. [PDF]

Hum Reprod Open
Cao Y, Bao S, Yang Q, Sun Y, Tang Y, Ju W, Liu J, Fang W, Wang X, Wu C, Li C, Zhu P, Shao S, Tao F, Pan G.   +14 more
europepmc   +1 more source

Nanocarrier‐Based Targeting of Pattern Recognition Receptors as an Innovative Strategy for Enhancing Sepsis Therapy

Advanced Healthcare Materials, EarlyView.
This review highlights recent progress in nanocarriers targeting pattern recognition receptors (PRRs), including Toll‐like and NOD‐like receptors, for enhancing the treatment of bacterial sepsis and related complications. These nanomedicines deliver antibiotics and anti‐inflammatory agents while modulating immune responses.
Eman A. Ismail, Vincent O. Nyandoro, Calvin A. Omolo, Thirumala Govender   +3 more
wiley   +1 more source

The Diagnostic Potential of Extracellular Vesicles Derived From the Blood Plasma of Glioblastoma Patients. [PDF]

In Vivo
Döring K, Malinova V, Bettag C, Rohde V, Schulz M, Menck K, Bleckmann A, Binder C, Büntzel J.   +8 more
europepmc   +1 more source

Lymphoid and CXCR4 Cell Targeted Lipid Nanoparticles Facilitate HIV‐1 Proviral DNA Excision

Advanced Healthcare Materials, EarlyView.
Advancements in ART improve HIV‐1 patient outcomes but are unable to eliminate latent viral DNA. To address this, CXCR4‐targeted lipid nanoparticles (T‐LNPs) for delivering CRISPR‐Cas9 to excise HIV‐1 DNA in infected cells are developed. These T‐LNPs achieve ≈60% HIV‐1 DNA excision efficacy in blood and splenic tissue, demonstrating promise for ...
Sudipta Panja, Lubaba A. Zaman, Chen Zhang, Milankumar Patel, Santhi Gorantla, Prasanta K. Dash, Howard E. Gendelman   +6 more
wiley   +1 more source

Influence of the Immune Checkpoint Inhibitors on the Hemostatic Potential of Blood Plasma. [PDF]

Transfus Med Hemother
Patalakh I, Wandersee A, Schlüter J, Erdmann M, Hackstein H, Cunningham S.   +5 more
europepmc   +1 more source

Investigation on the Influence of Protein Corona and Platelet Adhesion on Storage Bag Surface on the Platelet Storage Lesion

Advanced Healthcare Materials, EarlyView.
Platelet quality deteriorates during storage due to protein and platelet adhesion to current bag materials. Here, polymer coatings are identified that reduce adhesion and translated them to mini‐storage bags. Platelet quality are not impacted, despite significantly reducing adhesion.
Nicolas Pereyra, Kai Yu, Jason Rogalski, Taylor Olivia Da Silva, Parisa Golesorkhi, Madeleine Goldstein, Dana V. Devine, Jayachandran N. Kizhakkedathu   +7 more
wiley   +1 more source

Blood Plasma Methylated DNA Markers in the Detection of Lymphoma: Discovery, Validation, and Clinical Pilot. [PDF]

Am J Hematol
Witzig TE, Taylor WR, Mahoney DW, Bamlet WR, Foote PH, Burger KN, Doering KA, Devens ME, Arndt JR, O'Connell MC, Berger CK, Novak AJ, Cerhan JR, Hennek J, Katerov S, Allawi HT, Jevremovic D, Dao LN, Graham RP, Kisiel JB.   +19 more
europepmc   +1 more source

PLUS: Primary Layer for Universal Sensing Enabling Improved Immunocapture of Biomarkers in Clinical Scenarios

Advanced Healthcare Materials, EarlyView.
Primary Layer for Universal Sensing (PLUS), a universal coating for bioprobe immobilization across diverse substrates, is introduced. Unlike conventional methods, PLUS is directly grown from dopamine and avidin, creating a roughened surface with abundant biotin‐binding sites.
Nayoung Son, Chorok Byeon, Haejin Jeong, Hyeonha Jang, Jun Seok Park, Seonki Hong   +5 more
wiley   +1 more source

Blood Plasma, Fibrinogen or Fibrin Biomaterial for the Manufacturing of Skin Tissue-Engineered Products and Other Dermatological Treatments: A Systematic Review. [PDF]

J Funct Biomater
Sierra-Sánchez Á, Sanabria-de la Torre R, Ubago-Rodríguez A, Quiñones-Vico MI, Montero-Vílchez T, Sánchez-Díaz M, Arias-Santiago S.   +6 more
europepmc   +1 more source