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An Aptamer‐Based EXACT Anticoagulant as a Sustainable, Animal‐Free Alternative to Unfractionated Heparin

open access: yesAdvanced Science, EarlyView.
By simply conjugating thrombin's active‐site inhibitor, dabigatran, with an exosite inhibitor, aptamer HD1, the resulting EXosite‐ACTive site (EXACT) inhibitors show two orders of magnitude higher potency and selectivity via synergistic binding, while maintaining the aptamer's antidote‐reversible trait, yielding a potential substitute for the animal ...
Haixiang Yu   +11 more
wiley   +1 more source

Anti-HLA antibodies bound to monocytes altered antibody-mediated platelet phagocytosis and led to mild thrombocytopenia. [PDF]

open access: yesFront Immunol
Xu X   +11 more
europepmc   +1 more source
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Human blood platelets lack nitric oxide synthase activity

Platelets, 2015
Anke Böhmer, S. Gambaryan, D. Tsikas
semanticscholar   +1 more source

The control of blood platelets by cAMP signalling.

Biochemical Society Transactions, 2014
Z. Raslan, K. Naseem
semanticscholar   +1 more source

Morphology and enumeration of human blood platelets.

Journal of applied physiology, 1950
G. Brecher, E. Cronkite
semanticscholar   +1 more source

Circulating tumour DNA — looking beyond the blood

Nature Reviews Clinical Oncology, 2022
Ann Tivey, Matt Church, Natalie Cook
exaly  

The blood–tumour barrier in cancer biology and therapy

Nature Reviews Clinical Oncology, 2021
Patricia S Steeg
exaly  

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