Results 71 to 80 of about 3,276,607 (306)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Novel biomarkers in patients with uncontrolled hypertension with and without kidney damage

Blood Pressure
Introduction Estimated glomerular filtration rate (eGFR) and urine albumin/creatinine ratio (ACR) are insensitive biomarkers for early detection of hypertension-mediated organ damage (HMOD). In this nationwide cross-sectional study, we assessed potential
Karl Marius Brobak, Lene V. Halvorsen, Hans Christian D. Aass, Camilla L. Søraas, Arleen Aune, Eirik Olsen, Ola Undrum Bergland, Stine Rognstad, Kjersti B. Blom, Jon Arne K. Birkeland, Aud Høieggen, Anne Cecilie K. Larstorp, Marit D. Solbu   +12 more
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Improving blood pressure and dyslipidemia control by increasing health literacy in Croatia-missions 70/26 & Do you know what is your number

Blood Pressure
Purpose In 2022 hypertensive disease was the second cause of death in Croatia. The crude prevalence of hypertension is increasing and still majority of hypertensive patients did not reach blood pressure and cholesterol goals Low awareness, and small ...
Bojan Jelaković, Ivan Pećin, Valerija Bralić Lang, Marijana Braš, Krunoslav Capak, Ana Jelaković, Verica Kralj, Davor Miličić, Ana Soldo, Marija Bubaš   +9 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

The association between serum folate and elderly diastolic hypertension: results from the NHANES (2007–2018)

Blood Pressure
Aim To explore the association between serum folate concentration and the prevalence of elderly diastolic hypertension. This study aims to identify potential relationships that could inform further research into the mechanisms underlying hypertension ...
Hong Xie, Xiao-Feng Fan, Wen-Huan Shuai, Gui-You Zhong   +3 more
doaj   +1 more source

Pengaruh Teknik Relaksasi Otot Progresif Terhadap Tingkat Kecemasan Dan Penurunan Tekanan Darah Pada Pasien Hipertensi Di Rumah Sakit Islam Siti Khadijah Palembang [PDF]

, 2017
Background: According to WHO 2012 there are 839 million cases of hypertension, patients with hypertension more experienced by women (30%) and men (29%). Hypertension is an increase in blood pressure exceeding 160/95 mmHg.
Erviana, Nia
core  

The “Hypertension Approaches in the Elderly: a Lifestyle study” multicenter, randomized trial (HAEL Study): rationale and methodological protocol [PDF]

, 2019
Background: Hypertension is a clinical condition highly prevalent in the elderly, imposing great risks to cardiovascular diseases and loss of quality of life.
Alberton, Cristine Lima, Alves, Leonardo, Bock, Patrícia Martins, Botton, Cíntia Ehlers, Brizio, Maria Laura, Campelo, Paula, da Silveira, Anderson Donelli, De Nardi, Angélica Trevisan, Domingues, Marlos Rodrigues, Ferreira, Gustavo Dias, Galliano, Leony, Helal, Lucas, Mendes, Graciele Ferreira, Moraes, Ruy Silveira, Pescatello, Linda S., Pfeifer, Lucinéia Orsolin, Pinto, Stephanie Santana, Polanczyk, Carisi Anne, Santos, Lucas Porto, Schaan, Beatriz D., Schaun, Gustavo Zaccaria, Tanaka, Hirofumi, Umpierre, Daniel, Wilhelm, Eurico N.   +23 more
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Evaluation of self-monitoring of blood pressure in the PERHIT study and the impact on glomerular function

Blood Pressure
Background Although intensive blood pressure (BP) control has not been shown to slow the progression of chronic kidney disease (CKD), intensive BP control has been shown to reduce the risk for adverse cardiovascular outcomes in the CKD population.
Mikael Ekholm, Ulrika Andersson, Peter M. Nilsson, Karin Kjellgren, Patrik Midlöv   +4 more
doaj   +1 more source