Results 111 to 120 of about 233,375 (309)

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

FEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow, Isabel Brandtjen, Yaxin Mo, Melissa Gulley, Louis Osorio, Sagar Kudchodkar, Nandita C. Jhumur, Christine C. Roberts, Lisa K. Denzin, David I. Shreiber, Biju Parekkadan, Hao Lin, Joel N. Maslow   +12 more
wiley   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

Configuration, optimization and evaluation of a novel instrumental platform for automated SPE-LC-MS/MS analysis of drugs in whole blood [PDF]

, 2013
The thesis describes the configuration, optimization and evaluation of a novel instrumental platform for fully automated SPE-LC-MS/MS analysis of small molecules, such as drugs, in whole blood. The immunosuppressant Cyclosporine A was chosen as a model
Yu, Qianqian
core  

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

3D reconstruction of cerebral blood flow and vessel morphology from x-ray rotational angiography [PDF]

, 2009
Three-dimensional (3D) information on blood flow and vessel morphology is important when assessing cerebrovascular disease and when monitoring interventions.
Wächter, I., Wächter, I
core  

Standardization of In-Vitro Evaluation of Extracorporeal Life Support (ECLS) Devices for Research and Development. [PDF]

ASAIO J
Arens J, Belliato M, Broman LM, Clauser JC, Donker DW, Lorusso R, Malfertheiner M, Rajsic S, Swol J, Vercaemst L, Prahl Wittberg L, EACTS Innovation Committee, Section CPB, ECLS & MCS and the EuroELSO Innovation Group, EACTS Innovation Committee, Section CPB and ECLS & MCS and the EuroELSO Innovation Group.   +15 more
europepmc   +3 more sources

Relationship between Blood Pressure, Pulse Rate, Body Weight and Some Human Blood Groups among Stroke Subjects of Ogoni Ethnic Group

Sokoto Journal of Medical Laboratory Science, 2020
The aim of this study was to compare blood pressure, pulse rate and body weight and some blood group antigens (Lewis and ABO) among individuals of Ogoni ethnic group with stroke. This was a cross-sectional study carried out among indigenes of Ogoni whose
Evelyn Mgbeoma Eze , Serekara Gideon Christian * and Ibiere Allwell Pepple
doaj  

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Fiabilidade da medição da Tensão Arterial: revisão teórica La fiabilidad de la medida de presión arterial: revisión teórica Validity of arterial blood pressure measurement: theoretical review

Revista de Enfermagem Referência, 2010
A hipertensão arterial é um dos problemas de saúde pública mais importantes, sobretudo nos países desenvolvidos. É razoavelmente comum, facilmente diagnosticada e tem prognóstico reservado quando não tratada.
Mónica Santos, Cláudia Gomes
doaj