Results 51 to 60 of about 1,684,547 (311)

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Cuff-based blood pressure measurement: challenges and solutions

Blood Pressure
Objective Accurate measurement of arterial blood pressure (BP) is crucial for the diagnosis, monitoring, and treatment of hypertension. This narrative review highlights the challenges associated with conventional (cuff-based) BP measurement and potential
N. Pilz, D. S. Picone, A. Patzak, O. S. Opatz, T. Lindner, L. Fesseler, V. Heinz, T. L. Bothe   +7 more
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

When and how to use ambulatory blood pressure monitoring and home blood pressure monitoring for managing hypertension

Clinical Hypertension
Many individuals have different blood pressure (BP) values in the office setting compared to that outside the office setting. Therefore, confirming hypertension based on office BP (OBP) measurement alone can lead to misdiagnosis and mistreatment.
Eun Mi Lee
doaj   +1 more source

P.06 Comparison of Manual vs. Automated Haemodynamic Monitoring Systems in the Cardiac Catheterization Laboratory

Artery Research, 2020
Background: Hemodynamic monitoring is an integral part of a cardiac catheterization procedure; however it is prone to many distortions, including damping and resonance [1].
AbdulRehman Alanezi, Fayaz Mohammad Khan, Taher Alotaibi, Bandar Alhaddadi, Fahad Alanazi, Mohammad Alqahtani, Jaber Alsheri, Ali Masrahi, Faisal Aljumah, Hanan AlShamamry, Ziyad Alwasel, Mohammad Balghith, Kamal Ayoub, Ali Al Ghamdi, Azra Mahmud   +14 more
doaj   +1 more source

Nocturnal blood pressure rise as a predictor of cognitive impairment among the elderly: a retrospective cohort study

BMC Geriatrics, 2021
Background This study investigated the different blood pressure patterns that were evaluated by ambulatory blood pressure monitoring (ABPM) among elderly patients and explored the effect of pressure patterns on cognitive impairment and mortality. Methods
Yunli Xing, Ying Sun, Shan Wang, Feng Feng, Deqiang Zhang, Hongwei Li   +5 more
doaj   +1 more source

Blood pressure monitoring in sleep: time to wake up.

Blood Pressure Monitoring, 2019
Hypertension is a highly common condition with well-established adverse consequences. Ambulatory blood pressure monitoring has repeatedly been shown to better predict cardiovascular outcomes and mortality, compared to single office visit blood pressure ...
Younghoon Kwon, P. Stafford, D. Lim, Sungha Park, Sung-Hoon Kim, R. Berry, D. Calhoun   +6 more
semanticscholar   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Telehealth with remote blood pressure monitoring for postpartum hypertension: A prospective single-cohort feasibility study.

Pregnancy Hypertension, 2019
OBJECTIVE Investigate feasibility of telehealth with remote blood pressure monitoring for management of hypertension in postpartum women at risk of severe hypertension after hospital discharge.
K. Hoppe, Makeba Williams, Nicole Thomas, J. Zella, Anna Drewry, KyungMann Kim, T. Havighurst, H. Johnson   +7 more
semanticscholar   +1 more source

Effect of Self-monitoring of Blood Pressure on Blood Pressure Control in Pregnant Individuals With Chronic or Gestational Hypertension: The BUMP 2 Randomized Clinical Trial.

Journal of the American Medical Association (JAMA), 2022
Importance Inadequate management of elevated blood pressure is a significant contributing factor to maternal deaths. The role of blood pressure self-monitoring in pregnancy in improving clinical outcomes for the pregnant individual and infant is unclear.
L. Chappell, K. Tucker, Ushma Galal, Ly-Mee Yu, H. Campbell, O. Rivero-Arias, J. Allen, R. Band, A. Chisholm, C. Crawford, G. Dougall, Lazarina Engonidou, M. Franssen, Marcus Green, Sheila M. Greenfield, L. Hinton, J. Hodgkinson, L. Lavallee, P. Leeson, C. McCourt, L. Mackillop, J. Sandall, Mauro D. Santos, L. Tarassenko, Carmelo Velardo, H. Wilson, L. Yardley, R. McManus   +27 more
semanticscholar   +1 more source