Results 41 to 50 of about 1,554,164 (266)

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Glioblastoma and Blood Microenvironment Predictive Model for Life Expectancy of Patients

Biomedicines
Background: Glioblastoma multiforme (GBM) is a very malignant brain tumor. GBM exhibits cellular and molecular heterogeneity that can be exploited to improve patient outcomes by individually tailoring chemotherapy regimens.
Alexander N. Chernov, Sofia S. Skliar, Mikalai M. Yatskou, Victor V. Skakun, Sarng S. Pyurveev, Ekaterina G. Batotsyrenova, Sergey N. Zheregelya, Guodong Liu, Vadim A. Kashuro, Dmitry O. Ivanov, Sergey D. Ivanov   +10 more
doaj   +1 more source

CYPRINIDS TOTAL BLOOD PROTEINS DETERMINATION

Scientific Papers Animal Science and Biotechnologies, 2023
In aquaculture to get a high production is conditioned by awareness and keeping of an unaltered health condition of the biological material. To be aware of the health condition of the biological material in a fish farm allows us to establish the ...
TANŢI PATRICHE, N. PATRICHE, MAGDALENA TENCIU   +2 more
doaj  

Storage-Induced Platelet Apoptosis Is a Potential Risk Factor for Alloimmunization Upon Platelet Transfusion

Frontiers in Immunology, 2018
Platelet transfusion can elicit alloimmune responses leading to alloantibody formation against donor-specific polymorphic residues, ultimately resulting in platelet transfusion refractoriness.
Anno Saris, Anno Saris, Ivan Peyron, Pieter F. van der Meer, Tor B. Stuge, Jaap Jan Zwaginga, S. Marieke van Ham, S. Marieke van Ham, S. Marieke van Ham, Anja ten Brinke, Anja ten Brinke   +10 more
doaj   +1 more source

Characterization of blood-derived exosomal proteins after exercise

Journal of International Medical Research, 2020
Objective To assess changes in plasma exosome levels and protein content in mice after long-term exercise. Methods We subjected 9-month-old adult C57BL/6J mice to daily treadmill running exercise for 4 weeks prior to the isolation of blood-derived ...
Hongkai Xiang, Shisheng Chen, Junhan Zhou, Junxiu Guo, Qingfeng Zhou, Qishuang Zhou   +5 more
doaj   +1 more source

Mendelian randomization of circulating proteome identifies actionable targets in heart failure

BMC Genomics, 2022
Background Heart failure (HF) is a prevalent cause of mortality and morbidity. The molecular drivers of HF are still largely unknown. Results We aimed to identify circulating proteins causally associated with HF by leveraging genome-wide genetic ...
Louis-Hippolyte Minvielle Moncla, Samuel Mathieu, Mame Sokhna Sylla, Yohan Bossé, Sébastien Thériault, Benoit J. Arsenault, Patrick Mathieu   +6 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Structural and dynamic mechanisms of CBF3-guided centromeric nucleosome formation

Nature Communications, 2021
Chromosome segregation requires the association of the kinetochore protein complex with a specialized nucleosome at the centromere. Here, the authors present cryo-EM and mutational studies that provide insights into the structure of the budding yeast ...
Ruifang Guan, Tengfei Lian, Bing-Rui Zhou, Emily He, Carl Wu, Martin Singleton, Yawen Bai   +6 more
doaj   +1 more source

Pulmonary hypertension: Proteins in the blood

Global Cardiology Science and Practice, 2020
The plasma proteome is rich in information. It comprises proteins that are secreted or lost from cells as they respond to their local environment. Changes in the constitution of the plasma proteome offer a relatively non-invasive report on the health of tissues.
openaire   +4 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source