Results 41 to 50 of about 18,796 (219)

Storage-Induced Platelet Apoptosis Is a Potential Risk Factor for Alloimmunization Upon Platelet Transfusion

Frontiers in Immunology, 2018
Platelet transfusion can elicit alloimmune responses leading to alloantibody formation against donor-specific polymorphic residues, ultimately resulting in platelet transfusion refractoriness.
Anno Saris, Anno Saris, Ivan Peyron, Pieter F. van der Meer, Tor B. Stuge, Jaap Jan Zwaginga, S. Marieke van Ham, S. Marieke van Ham, S. Marieke van Ham, Anja ten Brinke, Anja ten Brinke   +10 more
doaj   +1 more source

Characterization of blood-derived exosomal proteins after exercise

Journal of International Medical Research, 2020
Objective To assess changes in plasma exosome levels and protein content in mice after long-term exercise. Methods We subjected 9-month-old adult C57BL/6J mice to daily treadmill running exercise for 4 weeks prior to the isolation of blood-derived ...
Hongkai Xiang, Shisheng Chen, Junhan Zhou, Junxiu Guo, Qingfeng Zhou, Qishuang Zhou   +5 more
doaj   +1 more source

Mendelian randomization of circulating proteome identifies actionable targets in heart failure

BMC Genomics, 2022
Background Heart failure (HF) is a prevalent cause of mortality and morbidity. The molecular drivers of HF are still largely unknown. Results We aimed to identify circulating proteins causally associated with HF by leveraging genome-wide genetic ...
Louis-Hippolyte Minvielle Moncla, Samuel Mathieu, Mame Sokhna Sylla, Yohan Bossé, Sébastien Thériault, Benoit J. Arsenault, Patrick Mathieu   +6 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Glioblastoma and Blood Microenvironment Predictive Model for Life Expectancy of Patients

Biomedicines
Background: Glioblastoma multiforme (GBM) is a very malignant brain tumor. GBM exhibits cellular and molecular heterogeneity that can be exploited to improve patient outcomes by individually tailoring chemotherapy regimens.
Alexander N. Chernov, Sofia S. Skliar, Mikalai M. Yatskou, Victor V. Skakun, Sarng S. Pyurveev, Ekaterina G. Batotsyrenova, Sergey N. Zheregelya, Guodong Liu, Vadim A. Kashuro, Dmitry O. Ivanov, Sergey D. Ivanov   +10 more
doaj   +1 more source

Structural and dynamic mechanisms of CBF3-guided centromeric nucleosome formation

Nature Communications, 2021
Chromosome segregation requires the association of the kinetochore protein complex with a specialized nucleosome at the centromere. Here, the authors present cryo-EM and mutational studies that provide insights into the structure of the budding yeast ...
Ruifang Guan, Tengfei Lian, Bing-Rui Zhou, Emily He, Carl Wu, Martin Singleton, Yawen Bai   +6 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The molecular mechanisms driving physiological changes after long duration space flights revealed by quantitative analysis of human blood proteins

BMC Medical Genomics, 2019
Background The conditions of space flight have a significant effect on the physiological processes in the human body, yet the molecular mechanisms driving physiological changes remain unknown.
Daria N. Kashirina, Andrew J. Percy, Liudmila Kh. Pastushkova, Christoph H. Borchers, Kirill S. Kireev, Vladimir A. Ivanisenko, Alexey S. Kononikhin, Eugene N. Nikolaev, Irina M. Larina   +8 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source