Results 121 to 130 of about 5,142,307 (313)

Exploring dog saliva as a non-invasive alternative to blood sampling for chemical exposome studies: analysis of synthetic phenolic antioxidants and PFAS

Frontiers in Veterinary Science
BackgroundHumans and companion animals are continually exposed to mixtures of synthetic chemicals from household products, textiles, food, and personal care items. Epidemiological studies of emerging contaminants typically rely on invasive blood sampling,
Jana M. Weiss, Josefin Engelhardt, Lorena Franco Martínez, Asta Tvarijonaviciute   +3 more
doaj   +1 more source

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

FEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa, Mohammed Nooh, Akhil Geddati, Alex Dopico, Anna N. Bukiya   +4 more
wiley   +1 more source

Assessment of the ability of SARS-CoV-2 strains of genetic variants B.1.1 and JN.1 to evade neutralizing antibodies from 2020 and 2023 convalescent patients

Инфекция и иммунитет
Introduction. The SARS-CoV-2 virus is a highly variable pathogen accounted for by random mutations leading to the emergence of new genetic variants. Natural selection of SARS-CoV-2 variants is, among other things, the result of population level immunity ...
Stepan A. Pyankov, A. V. Zaykovskaya, A. V. Rybel, S. A. Bodnev, O. V. Pyankov   +4 more
doaj   +1 more source

In vitro generation of regulatory T cells: A challenging tool for studying immune aging in humans

FEBS Open Bio, EarlyView.
In vitro induction of human regulatory T cells using standard protocols generates suppressive, Foxp3‐expressing CD4+ T cells independently of TGF‐β supplementation and donor age. Regulatory T (Treg) cells play a key role in immune tolerance and homeostasis.
Lynn Muller, Jana Bleher, Birgit Weinberger, Lourdes Rocamora‐Reverte   +3 more
wiley   +1 more source

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source

Study of biochemical indicators of blood serum of broiler chickens grown using a complex feed additive

Новые технологии, 2018
The article presents the results of a study of the effect of complex feed additives on the biochemical parameters of the blood serum of broiler chickens.
R. V. Kazaryan, M. V. Lukyanenko, A. S. Borodikhin, M. P. Semenenko, P. V. Miroshnichenko   +4 more
doaj  

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Blood urea nitrogen to serum albumin ratio independently predicts mortality and severity of community-acquired pneumonia

, 2012
Motoi Ugajin, Kenichi Yamaki, Natsuko Iwamura, Takeo Yagi, Takayuki AsanoDepartment of Respiratory Medicine, Ichinomiya-Nishi Hospital, Ichinomiya City, Aichi Prefecture, JapanBackground: Early studies of community-acquired pneumonia showed that ...
Yagi T, Asano T, Iwamura N, Yamaki K, Ugajin M   +4 more
core  

Study of antioxidant properties of food additives obtained from secondary vegetable resources in testing laboratory animals

Новые технологии, 2017
The data describing the composition of antioxidants contained in food additives obtained using innovative technologies from secondary plant resources formed at fruits and vegetables processing are given.
N. N. Kornen, A. N. Troshin, M. P. Semenenko, E. V. Kuzminova, T. A. Shakhrai   +4 more
doaj  

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source